ArticleJournal of medical virology2021
Evaluation of predictors of severe-moderate COVID-19 infections at children: A review of 292 children.
Article in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Epidemiology and clinical features of SARS-CoV-2 infection in children and adolescents in the pre-Omicron era: A global systematic review and meta-analysis.Journal of global health · 2024Pooled it
- Development and validation of a prediction model for infection in chronic nonhealing wounds: a two-center retrospective study with external validation.Frontiers in public health · 2026Article
- A Series of Severe and Critical COVID-19 Cases in Hospitalized, Unvaccinated Children: Clinical Findings and Hospital Care.Epidemiologia (Basel, Switzerland) · 2025Article
- Effect of COVID-19 Disease on Serum Vitamin D Status in Children with Asthma-A Retrospective Study.Journal of clinical medicine · 2025Article
- Risk factors of severe course and fatality in children hospitalized for COVID-19: a two-center cohort study.Archives of medical science : AMS · 2025Article
- Creatine Kinase as a Predictor of Disease Severity in Children with COVID-19.Medical journal of the Islamic Republic of Iran · 2025Article
- Severity Profile of COVID-19 in Hospitalized Pediatric Patients.Children (Basel, Switzerland) · 2024Article
- Clinical Outcomes of Pediatric Cancer Patients with COVID-19: A Cross-Sectional Study.International journal of hematology-oncology and stem cell research · 2024Article
- Treatment of Severe Asthma: Case Report of Fast Action of Mepolizumab in a Patient with Recent SARS-CoV-2 Infection.Life (Basel, Switzerland) · 2024Article
- Article
- COVID-19 and Comorbidities: What Has Been Unveiled by Metabolomics?Metabolites · 2024Review
- Impact of SARS-CoV-2 Infection in Children with Asthma and Impact of COVID-19 Vaccination: Current Evidence and Review of the Literature.Microorganisms · 2023Review
- Risk and Protective Factors for COVID-19 Morbidity, Severity, and Mortality.Clinical reviews in allergy & immunology · 2023Review
- Which Groups of Children Are at More Risk of Fatality during COVID-19 Pandemic? A Case-Control Study in Yazd, Iran.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Article
- Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic health.Biochimica et biophysica acta. Molecular basis of disease · 2022Review
- Low-grade inflammation, CoVID-19, and obesity: clinical aspect and molecular insights in childhood and adulthood.International journal of obesity (2005) · 2022Review
- Association between Coagulation Profile and Clinical Outcome in Children with SARS-CoV-2 Infection or MIS-C: A Multicenter Cross-Sectional Study.Children (Basel, Switzerland) · 2022Article
- Hematologic manifestations of coronavirus disease 2019 in children: Case-series report and a review.Frontiers in pediatrics · 2022Article
- Evaluation of predictors of severe-moderate COVID-19 infections at children: A review of 292 children.Journal of medical virology · 2021Article
- COVID-19 Pandemic as Risk Factors for Excessive Weight Gain in Pediatrics: The Role of Changes in Nutrition Behavior. A Narrative Review.Nutrients · 2021Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the underlying disease is associated with a severe course in adults and laboratory abnormalities have been widely reported, there are not sufficient data on the clinical course of coronavirus disease 2019 (COVID-19) in children with pre-existing comorbid conditions and on laboratory findings. We aimed to describe the independent risk factors for estimating the severity of the COVID-19 in children. All children between 1 month and 18 years old who were hospitalized during the period of March 11-December 31, 2020, resulting from COVID-19 were included in the study. Patients were categorized into mild (group 1) and moderate + severe/critically (group 2) severity based on the criteria. Demographic characteristics, comorbidities, and laboratory variables between the two groups were compared. A total of 292 children confirmed to have COVID-19 infection were included in the study. The most common associated diseases were obesity (5.1%) and asthma bronchiale (4.1%). We observed that disease progressed more severely in patients with underlying diseases, especially obesity and asthma bronchiale (for patients with obesity odds ratio [OR] 9.1, 95% confidence interval [CI] 1.92-43.28, p = 0.005 and for patients with asthma bronchiale OR 4.1, 95% CI 1.04-16.80, p = 0.044). In group 2 patients, presence of lymphopenia and hypoalbuminemia, and also an elevation in serum levels of C-reactive protein, procalcitonin, and uric acid were detected and these results were statistically significant (p values; p < 0.001, p = 0.046, p = 0.006, p = 0.045, p < 0.001, respectively). The strongest predictor of moderate-severe COVID-19 infections in the children was uric acid, with an odds ratio of 1.6 (95% CI 1.14-2.13, p = 0.005) and lymphocytes with an odds ratio of 0.7 (95% CI 0.55-0.88, p = 0.003). Although children are less susceptible to COVID-19, the pre-existing comorbid condition can predispose to severe disease. In addition, lymphopenia and high uric acid are indicators that COVID-19 infection may progress more severely.
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