Evidence map›Paper›PMID 34313962›Full record

ArticleAging clinical and experimental research2022

Influencing factors for the decline of limb muscle strength and the association with all-cause mortality: evidence from a nationwide population-based cohort study.

Jiaxiang Gao, Yudian Qiu, Yunfei Hou, Liyi Zhang, Kai Wang, Zhaoyu Chen, Qian Liu, Jianhao Lin

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Article in Aging clinical and experimental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jiaxiang Gao *Arthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Yudian Qiu *Department of Orthopedics, Beijing Hospital, National Center of Gerontology, Beijing, China.
Yunfei HouArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Liyi ZhangArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Kai WangArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Zhaoyu ChenArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Qian LiuArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China.
Jianhao LinArthritis Clinic & Research Center, Peking University People's Hospital, Peking University, Beijing, 100044, China. linjianhao@pkuph.edu.cn.
Peking University · CNPeking University People's Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

national major science and technology projects of china D171100003217002national major science and technology projects of china Z171100002717094national natural science foundation of china 81501919national natural science foundation of china 81973606
6 · The paper itself

Abstract

backgroundThe decline of muscle strength, a typical characteristic of sarcopenia, greatly affects aging-related health outcomes; however, prospective data on influencing factors and mortality in the Chinese population are relatively sparse.

aimsWe investigated the influencing factors for the declined limb muscle strength and the association with all-cause mortality among the elderly Chinese individuals aged ≥ 65 years in a large long-term prospective cohort study.

methodsWe used data from the China Health and Retirement Longitudinal Study (CHARLS). Logistic regression analyses were performed to investigate the influencing factors of declined limb muscle strength. Cox proportional hazard models were used to analyze the impact on all-cause mortality, whose performance was evaluated by train-test cross-validation.

resultsThe prevalences of declined upper and lower limb strength, which were defined by low hand grip strength (HS) and gait speed (GS), respectively, were 34.4% and 59.7%. The declined HS was significantly associated with older age (p < 0.001), female (p < 0.001), lower educational level (p < 0.001), lower BMI (p < 0.001), and combined with chronic diseases (p = 0.001). Moreover, the declined limb muscle strength was correlated with all-cause mortality (HR: 1.13, 95% CI 1.03-1.21 for HS; HR: 1.09, 95% CI 1.04-1.15 for GS), according to a multi-adjusted model with moderate predictive ability (C-index: 0.714, AUC of 7 year follow-up: 0.716).

conclusionsThe decline of limb muscle strength was prevalent among elderly Chinese individuals and had a strong impact on all-cause mortality. Identification of key populations and tailored interventions on their influencing factors should be implemented in further research.

Indexed as

Hand StrengthSarcopeniaAgedCohort StudiesFemaleHumansLongitudinal StudiesMuscle StrengthProspective StudiesAll-cause mortalityGait speedHand grip strengthInfluencing factorsLimb muscle strengthSarcopenia

Identifiers

PMID34313962
OpenAlexW3184363602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.