Association between rs3088440 (G > A) polymorphism at 9p21.3 locus with the occurrence and severity of coronary artery disease in an Iranian population.

Mitra Pourgholi, Omid Abazari, Leyla Pourgholi, Maryam Ghasemi-Kasman, Mohammadali Boroumand

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Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors at 3 institutions in 1 country.

Mitra PourgholiStudent Research Committee, Babol University of Medical Sciences, Babol, Iran.

Omid AbazariDepartment of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.

Leyla PourgholiDepartment of Pathology and Laboratory Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Maryam Ghasemi-KasmanCellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, P.O. Box 4136747176, Babol, Iran. m.ghasemi@mubabol.ac.ir.ORCID http://orcid.org/0000-0002-5014-5166

Mohammadali BoroumandDepartment of Pathology and Laboratory Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. maboroumand@yahoo.com.

Babol University of Medical Sciences · IRTehran University of Medical Sciences · IRShahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

Babol University of Medical Sciences 9705412

6 · The paper itself

Abstract

backgroundSeveral genome-wide association studies showed that a series of genetic variants located at the chromosome 9p21 locus are strongly associated with coronary artery disease (CAD). RATIONALE AND PURPOSE OF THE STUDY: In the present study, the relationship of rs3088440 (G > A) in cyclin-dependent kinase inhibitor 2A (CDKN2A) gene site with the presence of coronary artery disease (CAD) and its severity was evaluated in an Iranian population. METHODS AND

resultsThe presence of rs3088440 (G > A) genotypes was assessed by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) technique in 324 CAD patients and 148 normal controls. rs3088440 (G > A) polymorphism was associated with increased risk of CAD in the total population (adjusted OR = 1.76, 95% CI = 1.10-2.82; p-value = 0.017) or in women (adjusted OR = 2.96, 95% CI = 1.34-6.55; p-value = 0.007), but not in the men (adjusted OR = 1.35, 95% CI = 0.70-2.6; p-value = 0.368).

conclusionsOur findings suggest that the presence of rs3088440 (G > A) is potentially linked with the risk of CAD and its severity in whole study subjects or in women only, independent of CAD risk factors.

Indexed as

AgedAllelesCase-Control StudiesChromosomes, Human, Pair 9Coronary Artery DiseaseCyclin-Dependent Kinase Inhibitor p16FemaleGene FrequencyGenes, p16Genetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansIranMaleMiddle AgedCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p169p21.3 locusCoronary artery diseaseCyclin-dependent kinase inhibitor 2Ars3088440 polymorphismSingle nucleotide polymorphisms

Identifiers

PMID34313925

DOI10.1007/s11033-021-06587-4

OpenAlexW3183437793

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