Evidence map›Paper›PMID 34313915›Full record

ArticlePurinergic signalling2021

Lack of efficacy of a partial adenosine A1 receptor agonist in neuropathic pain models in mice.

Katharina Metzner, Tilman Gross, Annika Balzulat, Gesine Wack, Ruirui Lu, Achim Schmidtko

Open access · hybridAbstract read
In one paragraph

Article in Purinergic signalling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Ligand-Directed Labeling of the Adenosine AJournal of medicinal chemistry · 2024
    Article
  4. Targeting sensory neuron GPCRs for peripheral neuropathic pain.Trends in pharmacological sciences · 2023
    Review
  5. Article
  6. Adenosine Receptors as Potential Therapeutic Analgesic Targets.International journal of molecular sciences · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katharina MetznerInstitute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany. metzner@em.uni-frankfurt.de.
Tilman GrossInstitute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
Annika BalzulatInstitute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
Gesine WackInstitute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
Ruirui LuInstitute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
Achim SchmidtkoInstitute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
Goethe University Frankfurt · DE

Funding

HSRD VA CRE 12-023
6 · The paper itself

Abstract

Previous studies suggest that adenosine A

Indexed as

Adenosine A1 Receptor AgonistsAnimalsCells, CulturedFemaleMaleMiceMice, Inbred C57BLNeuralgiaPain MeasurementReceptor, Adenosine A1Treatment OutcomeAdenosine A1 Receptor AgonistsReceptor, Adenosine A1Adenosine A1 receptorIn situ hybridizationNeuropathic painPain behaviorPartial agonistPatch-clamp

Identifiers

PMID34313915
PMCPMC8410902
OpenAlexW3184973505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.