SynthesisPsychopharmacology2021
Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis.
Synthesis in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Brain Structural Abnormalities in Addiction Disorders: Transdiagnostic Meta-Analyses.Human brain mapping · 2026Pooled it
- Internet addiction-induced brain structure and function alterations: a systematic review and meta-analysis of voxel-based morphometry and resting-state functional connectivity studies.Brain imaging and behavior · 2023Pooled it
- Distinct brain structural abnormalities in attention-deficit/hyperactivity disorder and substance use disorders: A comparative meta-analysis.Translational psychiatry · 2022Pooled it
- Meta-analysis of structural and functional brain alterations in internet gaming disorder.Frontiers in psychiatry · 2022Pooled it
- Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.Molecular psychiatry · 2026Article
- Neurostructural Correlates and Impulsive Mechanisms of Exercise Dependence in Middle-Aged and Elderly Adults: Evidence from Gray Matter and Structural Covariance Networks.Brain topography · 2026Article
- Network localization of gray matter alterations in chronic smokers using the normative functional connectome.Frontiers in public health · 2026Article
- Grey Matter Volume in Substance Use: A Preregistered, Dimensional Approach to Disentangle Substance Use and Disorder Severity.Addiction biology · 2025Article
- Smoking and High-Altitude Exposure Affect Intrinsic Neural Activity: A fMRI Study of Interactive Effects.Addiction biology · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.medRxiv : the preprint server for health sciences · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.Frontiers in psychiatry · 2025Article
- Unmasking the Dark Triad: A Data Fusion Machine Learning Approach to Characterize the Neural Bases of Narcissistic, Machiavellian and Psychopathic Traits.The European journal of neuroscience · 2025Article
- Similarities and Differences in Neuroimaging.Advances in experimental medicine and biology · 2025Review
- Let's focus on the insula in addiction: A refined anatomical exploration of insula in severe alcohol and cocaine use disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Neuroimaging Biomarkers in Addiction.medRxiv : the preprint server for health sciences · 2024Article
- Stress and substance use disorders: risk, relapse, and treatment outcomes.The Journal of clinical investigation · 2024Review
- Altered insular functional activity among electronic cigarettes users with nicotine dependence.Translational psychiatry · 2024Article
- Brain alterations in individuals with exercise dependence: A multimodal neuroimaging investigation.Journal of behavioral addictions · 2024Article
- White matter integrity of right frontostriatal circuit predicts internet addiction severity among internet gamers.Addiction biology · 2024Article
- The Brain Salience Network at the Intersection of Pain and Substance use Disorders: Insights from Functional Neuroimaging Research.Current addiction reports · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNumerous studies based on voxel-based morphometry (VBM) have revealed gray matter (GM) alterations in multiple brain regions for addiction. However, findings are poorly replicated, and it remains elusive whether distinct diagnoses of addiction are underpinned by shared abnormalities. Our aim was to conduct a quantitative meta-analysis of structural neuroimaging studies investigating GM abnormalities in two main categories of addiction: substance use disorders (SUD) and behavioral addictions (BA).
methodA systematic database search was conducted in several databases from Jan 1, 2010, to Oct 23, 2020, to identify eligible VBM studies. Meta-analysis was performed with the seed-based d mapping software package to compare alternations between individuals with addiction-related disorders and healthy controls (HC).
resultsA total of 59 VBM studies including 2096 individuals with addiction-related disorders and 2637 HC met the inclusion criteria. Individuals with addiction-related disorders showed shared GM volume decrease in bilateral prefrontal cortex, bilateral insula, bilateral rolandic operculum, left superior temporal gyrus, and right Heschl gyrus and GM increase in right lingual gyrus and right fusiform gyrus comparing with HC (p < 0.005). Subgroup analysis found heterogeneity between SUD and BA mainly in left inferior occipital gyrus and right striatum (p < 0.005). Meta-regression revealed that GM atrophy in right anterior cingulate (r = 0.541, p = 0.03 (uncorrected)) and left inferior frontal gyrus (r = 0.595, p = 0.015) were positively correlated with higher impulsivity.
conclusionsThis meta-analysis identified a concordance across subtypes of addiction in terms of the brain structural changes in prefrontal and insula areas, which may relate to higher impulsivity observed across addiction diagnoses. This concordance provides an organizing model that emphasizes the importance of shared neural substrates in addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.