Evidence map›Paper›PMID 34313767›Full record

ArticleSchizophrenia bulletin2022

Autistic Symptoms and Social Functioning in Psychosis: A Network Approach.

Adela-Maria Isvoranu, Tim Ziermans, Frederike Schirmbeck, Denny Borsboom, Hilde M Geurts, Lieuwe de Haan, GROUP Investigators

Open access · bronzeAbstract read
In one paragraph

Article in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. The Network Model of Mentalization, Social Vulnerability, and the Self in Autism: A Comparison With Neurotypical Adults.Autism research : official journal of the International Society for Autism Research · 2026
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  16. Triple X syndrome: Psychiatric disorders and impaired social functioning as a risk factor.European psychiatry : the journal of the Association of European Psychiatrists · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Adela-Maria IsvoranuDepartment of Psychology, Psychological Methods, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-7981-9198
Tim ZiermansDepartment of Psychology, Brain and Cognition, Dutch Autism and ADHD Research Center (d'Arc), University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-5224-1365
Frederike SchirmbeckDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Denny BorsboomDepartment of Psychology, Psychological Methods, University of Amsterdam, Amsterdam, The Netherlands.
Hilde M GeurtsDepartment of Psychology, Brain and Cognition, Dutch Autism and ADHD Research Center (d'Arc), University of Amsterdam, Amsterdam, The Netherlands.
Lieuwe de HaanDepartment of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
GROUP Investigators
University of Amsterdam · NLAmsterdam University Medical Centers · NLKing's College London · GBUniversity Medical Center Groningen · NLArkin · NLMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychotic and autistic symptoms are related to social functioning in individuals with psychotic disorders (PD). The present study used a network approach to (1) evaluate the interactions between autistic symptoms, psychotic symptoms, and social functioning, and (2) investigate whether relations are similar in individuals with and without PD. We estimated an undirected network model in a sample of 504 PD, 572 familial risk for psychosis (FR), and 337 typical comparisons (TC), with a mean age of 34.9 years. Symptoms were assessed with the Autism Spectrum Quotient (AQ; 5 nodes) and the Community Assessment of Psychic Experiences (CAPE; 9 nodes). Social functioning was measured with the Social Functioning Scale (SFS; 7 nodes). We identified statistically significant differences between the FR and PD samples in global strength (P < .001) and network structure (P < .001). Our results show autistic symptoms (social interaction nodes) are negatively and more closely related to social functioning (withdrawal, interpersonal behavior) than psychotic symptoms. More and stronger connections between nodes were observed for the PD network than for FR and TC networks, while the latter 2 were similar in density (P = .11) and network structure (P = .19). The most central items in strength for PD were bizarre experiences, social skills, and paranoia. In conclusion, specific autistic symptoms are negatively associated with social functioning across the psychosis spectrum, but in the PD network symptoms may reinforce each other more easily. These findings emphasize the need for increased clinical awareness of comorbid autistic symptoms in psychotic individuals.

Indexed as

Psychosocial FunctioningSocial InteractionSocial SkillsAdultAutism Spectrum DisorderFemaleHumansMaleMiddle AgedPsychotic DisordersSchizophreniaSocial Network AnalysisYoung Adultautismfunctional outcomenetwork analysisnetwork modelspsychosisschizophrenia

Identifiers

PMID34313767
PMCPMC8781349
OpenAlexW3183352107

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.