Trial reportThe Journal of clinical endocrinology and metabolism2021
Weight Loss Prior to Pregnancy and Early Gestational Glycemia: Prepare, a Randomized Clinical Trial.
Trial report in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Preconception Interventions in Women at High Risk of Developing Gestational Diabetes: A Systematic Review.Maternal and child health journal · 2026Pooled it
- Long-term metabolic consequences ofFrontiers in endocrinology · 2026Pooled it
- Pre-Pregnancy Diet and/or Physical Activity Interventions for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.The Australian & New Zealand journal of obstetrics & gynaecology · 2025Pooled it
- No Effect of Prepregnancy Weight Loss Intervention on Child Weight up to Age 5.Childhood obesity (Print) · 2026Trial
- Time restricted eating and exercise training before and during pregnancy for people with increased risk of gestational diabetes: single centre randomised controlled trial (BEFORE THE BEGINNING).BMJ (Clinical research ed.) · 2025Trial
- Gestational weight loss relative to prepregnancy weight in women with gestational diabetes: impact on maternal and neonatal outcomes.Endocrine · 2026Article
- Therapeutic Potential of Anti-Obesity Drugs in Obesity-Associated Female Reproductive Dysfunction: Translating Mechanistic Evidence into Personalized Clinical Strategies.Medicina (Kaunas, Lithuania) · 2026Review
- Pregnancy after bariatric surgery: persistent obesity and longer time to conception influences peripartum outcomes more than the type of operation.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2026Article
- Preconception Weight Loss to Prevent Childhood Obesity: Current Evidence and Research Gaps.Current obesity reports · 2026Review
- Association of Prepregnancy Cardiometabolic Factors With Gestational Diabetes Among Asian Populations in the United States.JACC. Asia · 2024Article
- BMI status and weight trajectories across females' reproductive years and risk of adverse pregnancy outcomes: a prospective cohort study.The American journal of clinical nutrition · 2024Article
- Effective interventions in preventing gestational diabetes mellitus: A systematic review and meta-analysis.Communications medicine · 2024Article
- Pregnancy as an Early Cardiovascular Moment: Peripartum Cardiovascular Health.Circulation research · 2023Review
- The Impact of Gestational Weight Gain on Glucose and Insulin Physiology in Pregnancy-Does Timing Matter?The Journal of clinical endocrinology and metabolism · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
contextWomen with elevated body mass index are encouraged to lose weight before pregnancy, but no trials have tested the effects of prepregnancy weight loss on risk of developing gestational diabetes.
objectiveThis work aims to determine whether prepregnancy weight loss improved the early metabolic environment as measured by early gestational diabetes diagnosis.
methodsThis was a secondary analysis of a pragmatic randomized clinical trial conducted between May 2015 and October 2019 in an integrated health system that encouraged first-trimester gestational diabetes screening for high-risk women, including those with obesity. Women aged 18 to 40 years with a body mass index (BMI) greater than or equal to 27 who were planning pregnancy were randomly assigned to a behavioral weight loss intervention or usual care. Clinical care decisions and data collection were blind to condition assignment. We compared rates of diagnosis with gestational diabetes in early pregnancy between the groups using logistic regression.
resultsOf 326 participants, 168 (89 in the intervention and 79 in usual care) had singleton pregnancies during the study period. At baseline, mean age was 31.3 ± 3.5 years and BMI was 34.8 ± 5.8. Fifty-nine (66%) intervention participants and 57 (72%) usual care participants underwent early screening. Among those, intervention participants were 73% less likely to be diagnosed with gestational diabetes than usual care participants (adjusted odds ratio [aOR], 0.27; 95% CI, 0.09-0.80). There was no difference in diagnosis of gestational diabetes in later pregnancy (aOR, 1.08; 95% CI, 0.41-2.81).
conclusionParticipation in a prepregnancy weight loss intervention led to lower rates of gestational diabetes diagnosis in early pregnancy. This suggests positive effects of prepregnancy weight loss on the early metabolic environment, a critical factor in offspring metabolic risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.