ArticleCerebral cortex (New York, N.Y. : 1991)2021
Neurite Imaging Reveals Widespread Alterations in Gray and White Matter Neurite Morphology in Healthy Aging and Amnestic Mild Cognitive Impairment.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Disentangling in-vivo microstructural changes of white and gray matter in mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis.Brain imaging and behavior · 2023Pooled it
- Gray Matter Microstructure Measured Using Diffusion Imaging as a Biomarker of Severity in Lewy Body Diseases.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- Prefrontal and hippocampal microstructural gray matter following cognitive training under moderate hypoxia in mood disorders: a randomized controlled trial.Frontiers in neuroscience · 2026Article
- Neurite orientation dispersion and density imaging reveals microstructural damage in moyamoya disease: a study based on tract- and gray-based spatial statistics.BMC medical imaging · 2025Article
- Associations between temporal lobe cortical NODDI measures and memory function in individuals without clinical dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Mapping the neurodevelopmental predictors of psychopathology.Molecular psychiatry · 2025Article
- Predilection for Perplexion: Preoperative microstructural damage is linked to postoperative delirium.medRxiv : the preprint server for health sciences · 2025Article
- High resolution diffusion tensor imaging of the human cortex reveals non-linear trajectories over the healthy lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Perivascular space diffusivity and brain microstructural measures are associated with circadian time and sleep quality.Journal of sleep research · 2024Article
- Age-related alterations in human cortical microstructure across the lifespan: Insights from high-gradient diffusion MRI.Aging cell · 2024Article
- Neuronal microstructural changes in the human brain are associated with neurocognitive aging.Aging cell · 2024Article
- Cortical neurite microstructural correlates of time perception in healthy older adults.Heliyon · 2024Article
- Medial temporal lobe gray matter microstructure in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Aberrant microstructural integrity of white matter in mild and severe orthostatic hypotension: A NODDI study.CNS neuroscience & therapeutics · 2024Article
- Neuronal microstructural changes in the human brain are associated with neurocognitive aging.bioRxiv : the preprint server for biology · 2024Article
- Age-Related Alterations in Gray Matter Microstructure in Older People With Remitted Major Depression at Risk for Dementia.Biological psychiatry global open science · 2024Article
- Measures of cortical microstructure are linked to amyloid pathology in Alzheimer's disease.Brain : a journal of neurology · 2023Article
- Hypothalamic microstructure and function are related to body mass, but not mental or cognitive abilities across the adult lifespan.GeroScience · 2023Article
- Impact of asthma on the brain: evidence from diffusion MRI, CSF biomarkers and cognitive decline.Brain communications · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Aging is the major risk factor for neurodegenerative diseases and affects neurite distributions throughout the brain, yet underlying neurobiological mechanisms remain unclear. Multi-shell diffusion-weighted imaging and neurite orientation dispersion and density imaging (NODDI) now provide in vivo biophysical measurements that explain these biological processes in the cortex and white matter. In this study, neurite distributions were evaluated in the cortex and white matter in healthy older adults and patients with amnestic mild cognitive impairment (aMCI) that provides fundamental contributions regarding healthy aging and neurodegeneration. Older age was associated with reduced neurite density and neurite orientation dispersion (ODI) in widespread cortical regions. In contrast, increased ODI was only observed in the right thalamus and hippocampus with age. For the first time, we also reported a widespread age-associated decrease in neurite density along major white matter tracts correlated with decreased cortical neurite density in the tract endpoints in healthy older adults. We further examined alterations in cortical and white matter neurite microstructures in aMCI patients and found significant neurite morphology deficits in memory networks correlated with memory performance. Our findings indicate that neurite parameters provide valuable information regarding cortical and white matter microstructure and complement myeloarchitectural information in healthy aging and aMCI.
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