Evidence map›Paper›PMID 34313586›Full record

ArticleeLife2021

Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants.

Tatiana P Soares da Costa, Cody J Hall, Santosh Panjikar, Jessica A Wyllie, Rebecca M Christoff, Saadi Bayat, Mark D Hulett, Belinda M Abbott, Anthony R Gendall, Matthew A Perugini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Metabolomic Profiling Identifies Key Metabolites and Defense Pathways inInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tatiana P Soares da Costa *Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.ORCID 0000-0002-6275-7485
Cody J Hall *Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.
Santosh PanjikarAustralian Synchrotron, ANSTO, Clayton, Australia.ORCID 0000-0001-7429-3879
Jessica A WyllieDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.
Rebecca M ChristoffDepartment of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.
Saadi BayatDepartment of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.
Mark D HulettDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.ORCID 0000-0003-2072-5968
Belinda M AbbottDepartment of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.
Anthony R GendallDepartment of Animal, Plant and Soil Sciences, AgriBio, La Trobe University, Bundoora, Australia.ORCID 0000-0002-2255-3939
Matthew A PeruginiDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia.
La Trobe University · AUAustralian Nuclear Science and Technology Organisation · AUAustralian Research Council · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Weeds are becoming increasingly resistant to our current herbicides, posing a significant threat to agricultural production. Therefore, new herbicides with novel modes of action are urgently needed. In this study, we exploited a novel herbicide target, dihydrodipicolinate synthase (DHDPS), which catalyses the first and rate-limiting step in lysine biosynthesis. The first class of plant DHDPS inhibitors with micromolar potency against

Indexed as

ArabidopsisHerbicidesHydro-LyasesLysinePlants, Genetically Modified4-hydroxy-tetrahydrodipicolinate synthaseHerbicidesHydro-LyasesLysineA. thalianabiochemistrychemical biologyenzymesherbicidelysineplant biology

Identifiers

PMID34313586
PMCPMC8341977
OpenAlexW3183297520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.