ArticleeLife2021
Perception of microstimulation frequency in human somatosensory cortex.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 88 citations in OpenAlex.
- Biomimetic stimulation patterns drive natural artificial touch percepts using intracortical microstimulation in humans.Journal of neural engineering · 2025Trial
- Intracortical Somatosensory Stimulation to Elicit Fingertip Sensations in an Individual With Spinal Cord Injury.Neurology · 2022Trial
- [Neuroprosthetics].Chirurgie (Heidelberg, Germany) · 2026Review
- Integration of learned artificial sensation with vision during freely moving navigation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neural mechanisms underlying intracortical microstimulation for sensory restoration.Nature biomedical engineering · 2026Review
- Brain-computer interfaces as a causal probe for scientific inquiry.Trends in cognitive sciences · 2026Review
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Visual context affects the perceived timing of tactile sensations elicited through intracortical microstimulation: a case study of two participants.Journal of neurophysiology · 2025Article
- Disentangling indirect versus direct effects of somatosensory cortex microstimulation on neurons in primary motor and ventral premotor cortex.Journal of neural engineering · 2025Article
- Training-Free Regulation of Grasping by Intracortical Tactile Feedback Designed via S1-M1 Communication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Revolutionizing brain‒computer interfaces: overcoming biocompatibility challenges in implantable neural interfaces.Journal of nanobiotechnology · 2025Review
- Article
- Optimization frameworks for bespoke sensory encoding in neuroprosthetics.APL bioengineering · 2025Article
- Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex.Nature biomedical engineering · 2025Article
- The Next Frontier in Neuroprosthetics: Integration of Biomimetic Somatosensory Feedback.Biomimetics (Basel, Switzerland) · 2025Review
- Tactile edges and motion via patterned microstimulation of the human somatosensory cortex.Science (New York, N.Y.) · 2025Article
- Neural Mechanisms Underlying Robust Target Selection in Response to Microstimulation of the Oculomotor System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Tactile exploration and imagery elicit distinct neural dynamics in the parietal cortical network.Frontiers in neuroscience · 2025Article
- Investigating the spatial limits of somatotopic and depth-dependent sensory discrimination stimuli in rats via intracortical microstimulation.Frontiers in neuroscience · 2025Article
- Optimal interphase delay in biphasic current pulses facilitates neural circuit activation induced by microstimulation in the mouse visual cortex.Frontiers in neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Microstimulation in the somatosensory cortex can evoke artificial tactile percepts and can be incorporated into bidirectional brain-computer interfaces (BCIs) to restore function after injury or disease. However, little is known about how stimulation parameters themselves affect perception. Here, we stimulated through microelectrode arrays implanted in the somatosensory cortex of two human participants with cervical spinal cord injury and varied the stimulus amplitude, frequency, and train duration. Increasing the amplitude and train duration increased the perceived intensity on all tested electrodes. Surprisingly, we found that increasing the frequency evoked more intense percepts on some electrodes but evoked less-intense percepts on other electrodes. These different frequency-intensity relationships were divided into three groups, which also evoked distinct percept qualities at different stimulus frequencies. Neighboring electrode sites were more likely to belong to the same group. These results support the idea that stimulation frequency directly controls tactile perception and that these different percepts may be related to the organization of somatosensory cortex, which will facilitate principled development of stimulation strategies for bidirectional BCIs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.