ArticleeLife2021
Cortical excitability signatures for the degree of sleepiness in human.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Quantitative evaluation of low-frequency oscillations using real-time phase-contrast MRI during drowsiness.Fluids and barriers of the CNS · 2025Article
- Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics.Nature neuroscience · 2025Article
- Review
- Defective Intracortical Inhibition as a Marker of Impaired Neural Compensation in Amputees Undergoing Rehabilitation.Biomedicines · 2025Article
- Attentional failures after sleep deprivation represent moments of cerebrospinal fluid flow.bioRxiv : the preprint server for biology · 2024Article
- Blink-related arousal network surges are shaped by cortical vigilance states.Research square · 2024Article
- Sleep deprivation drives brain-wide changes in cholinergic presynapse abundance inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Effects of sleep deprivation on cortical excitability: A threshold-tracking TMS study and review of the literature.Clinical neurophysiology practice · 2024Article
- Natural brain state change with E/I balance shifting toward inhibition is associated with vigilance impairment.iScience · 2023Article
- Circadian distribution of epileptiform discharges in epilepsy: Candidate mechanisms of variability.PLoS computational biology · 2023Article
- Promising applications of non-invasive brain stimulation on military cognition enhancement: a long way to go.General psychiatry · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is essential in maintaining physiological homeostasis in the brain. While the underlying mechanism is not fully understood, a 'synaptic homeostasis' theory has been proposed that synapses continue to strengthen during awake and undergo downscaling during sleep. This theory predicts that brain excitability increases with sleepiness. Here, we collected transcranial magnetic stimulation measurements in 38 subjects in a 34 hr program and decoded the relationship between cortical excitability and self-report sleepiness using advanced statistical methods. By utilizing a combination of partial least squares regression and mixed-effect models, we identified a robust pattern of excitability changes, which can quantitatively predict the degree of sleepiness. Moreover, we found that synaptic strengthen occurred in both excitatory and inhibitory connections after sleep deprivation. In sum, our study provides supportive evidence for the synaptic homeostasis theory in human sleep and clarifies the process of synaptic strength modulation during sleepiness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.