ArticleThe neuroradiology journal2022
Brain structural differences in temporal lobe and frontal lobe epilepsy patients: A voxel-based morphometry and vertex-based surface analysis.
Article in The neuroradiology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Incidence of temporal thumb sign in adult patients with idiopathic seizures with and without elevated opening cerebrospinal fluid pressure.European radiology · 2025Article
- Cortical and subcortical morphometric changes in patients with frontal focal cortical dysplasia type II.Neuroradiology · 2025Article
- Structural brain characteristics of epilepsy patients with comorbid migraine without aura.Scientific reports · 2024Article
- Radiologic Classification of Hippocampal Sclerosis in Epilepsy.AJNR. American journal of neuroradiology · 2024Review
- MRI evidence for material-specific encoding deficits and mesial-temporal alterations in presurgical frontal lobe epilepsy patients.Epilepsia open · 2024Article
- Topological abnormality of structural covariance network in MRI-negative frontal lobe epilepsy.Frontiers in neuroscience · 2023Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeExploration of the effect of chronic recurrent seizures in focal epilepsy on brain volumes has produced many conflicting reports. To determine differences in brain structure in temporal lobe epilepsy (TLE) and extratemporal epilepsy (using frontal lobe epilepsy (FLE) a surrogate) further, we performed a retrospective analysis of a large cohort of patients with seizure-onset zone proven by intracranial monitoring.
methodsA total of 120 TLE patients, 86 FLE patients, and 54 healthy controls were enrolled in this study. An analysis of variance of voxel-based morphometry (VBM) was used to seek morphometric brain differences among TLE patients, FLE patients, and healthy controls. Additionally, a vertex-based surface analysis was utilized to analyze the hippocampus and thalamus. Significant side-specific differences in hippocampal gray matter volume were present between the left TLE (LTLE), right TLE RTLE (RTLE), and control groups (
resultsVertex analyses revealed significant volume reduction in inferior parts of the left hippocampus in the LTLE group and lateral parts of the right hippocampus in the RTLE group compared to controls (
conclusionOur results highlight the variation in morphometric lateralized changes in the brain between different epilepsy onset zones, providing critical insight into the natural history of people with drug-resistant focal epilepsies.
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