ArticleHuman brain mapping2021
Dynamic functional connectivity profile of the salience network across the life span.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Resting state functional connectivity changes following mindfulness-based stress reduction predict improvements in disease control for patients with asthma.Brain, behavior, and immunity · 2024Trial
- The Effect of AoA-L2 on Functional Network Dynamics in Bilinguals.Brain topography · 2026Article
- Dynamic functional connectivity in borderline personality disorder: associations with trauma, emotion regulation and symptom severity.European archives of psychiatry and clinical neuroscience · 2026Article
- A Multiscale Spatiotemporal Causal Mapping Algorithm for Revealing Neural Network Mechanisms of Transcutaneous Auricular Vagus Nerve Stimulation.Human brain mapping · 2026Article
- Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth.Biological psychiatry global open science · 2026Article
- Brain Network Patterns in Patients With Multiple System Atrophy: Spatial Independent Component Analysis Using FDG-PET Data.Neurology · 2026Article
- Altered Brain Network Dynamics in Schizophrenia Patients With Predominant Negative Symptoms: A Resting-State fMRI Study Using Co-Activation Pattern Analysis.Human brain mapping · 2025Article
- Social pain is associated with altered developmental trajectories of connectivity among the triple network model of psychopathology.Social cognitive and affective neuroscience · 2025Article
- Supercomplexity: bridging the gap between aesthetics and cognition.Frontiers in neuroscience · 2025Article
- Beyond NMDA Receptors: A Narrative Review of Ketamine's Rapid and Multifaceted Mechanisms in Depression Treatment.International journal of molecular sciences · 2024Review
- Frontoparietal network integrity supports cognitive function in pre-symptomatic frontotemporal dementia: Multimodal analysis of brain function, structure, and perfusion.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Energy Associated With Dynamic Network Changes in Patients With Multiple Sclerosis and Cognitive Impairment.Neurology · 2024Article
- Prenatal Exposure to Maternal Mood Entropy Is Associated With a Weakened and Inflexible Salience Network in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Fingerprints of decreased cognitive performance on fractal connectivity dynamics in healthy aging.GeroScience · 2024Article
- Developmental trajectories of the default mode, frontoparietal, and salience networks from the third trimester through the newborn period.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Functional connectivity gradients of the cingulate cortex.Communications biology · 2023Article
- The relationship between alexithymia, interoception, and neural functional connectivity during facial expression processing in autism spectrum disorder.Neuropsychologia · 2023Article
- Individual functional parcellation revealed compensation of dynamic limbic network organization in healthy ageing.Human brain mapping · 2023Article
- Characterizing the spatiotemporal features of functional connectivity across the white matter and gray matter during the naturalistic condition.Frontiers in neuroscience · 2023Article
- The influence of childhood emotional neglect experience on brain dynamic functional connectivity in young adults.European journal of psychotraumatology · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
The insular cortex and anterior cingulate cortex together comprise the salience or midcingulo-insular network, involved in detecting salient events and initiating control signals to mediate brain network dynamics. The extent to which functional coupling between the salience network and the rest of the brain undergoes changes due to development and aging is at present largely unexplored. Here, we examine dynamic functional connectivity (dFC) of the salience network in a large life span sample (n = 601; 6-85 years old). A sliding-window analysis and k-means clustering revealed five states of dFC formed with the salience network, characterized by either widespread asynchrony or different patterns of synchrony between the salience network and other brain regions. We determined the frequency, dwell time, total transitions, and specific state-to-state transitions for each state and subject, regressing the metrics with subjects' age to identify life span trends. A dynamic state characterized by low connectivity between the salience network and the rest of the brain had a strong positive quadratic relationship between age and both frequency and dwell time. Additional frequency, dwell time, total transitions, and state-to-state transition trends were observed with other salience network states. Our results highlight the metastable dynamics of the salience network and its role in the maturation of brain regions critical for cognition.
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