SynthesisAesthetic plastic surgery2021
Histological Analyses of Capsular Contracture and Associated Risk Factors: A Systematic Review.
Synthesis in Aesthetic plastic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Does Patient History Influence Capsular Contracture? An Exploratory Analysis with Machine Learning.Aesthetic plastic surgery · 2026Article
- Balancing Risk and Reconstruction: A Comprehensive Review of Complications in Delayed Breast Reconstruction.Journal of clinical medicine · 2026Review
- A Global Propensity Score-matched Analysis of 56,992 Nicotine-dependent Versus Nondependent Breast Reconstruction Cases.Plastic and reconstructive surgery. Global open · 2026Article
- Capsular Contracture in Implant-Based Breast Reconstruction: A Comprehensive Narrative Review of Pathophysiology, Risk Factors, and Contemporary Controversies.Medicina (Kaunas, Lithuania) · 2026Review
- Soft Tissue Scaffolds in Breast Reconstruction: Evolution from Acellular Dermal Matrices to Synthetic Polymers.Journal of clinical medicine · 2026Review
- Selective Pectoralis Muscle Denervation Reduces Capsular Contracture in Sub-Pectoral Breast Reconstruction. Long-Term Retrospective Case- Control Study.ANZ journal of surgery · 2026Article
- Investigating the foreign body response and regenerative mechanisms in medical-grade polycaprolactone scaffold guided breast reconstruction in a porcine model.Frontiers in bioengineering and biotechnology · 2026Article
- Adipose-derived mesenchymal stem cells for the prevention of capsular contracture.Journal of molecular medicine (Berlin, Germany) · 2025Article
- State of Research on Tissue Engineering with 3D Printing for Breast Reconstruction.Journal of clinical medicine · 2025Review
- A Histological Assessment Tool for Breast Implant Capsules Validated in 480 Patients with and Without Capsular Contracture.Aesthetic plastic surgery · 2025Article
- Analysis of risk factors for capsular contracture after breast augmentation: a retrospective study.Frontiers in surgery · 2025Article
- Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of breast capsular contracture.Genes & diseases · 2024Article
- Article
- Implant-based breast surgery and capsular formation: when, how and why?-a narrative review.Annals of translational medicine · 2023Review
- Breast Implant Capsule: A Murine Model Comparing Capsular Contracture Susceptibility Among Six Breast Implants Available in the Market.Aesthetic plastic surgery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCapsular contracture is a severe complication to breast surgery with implants. Previous studies suggest multiple risk factors are associated with capsular contracture, but the etiology is still unknown. We performed a literature review to investigate existing studies on histological analyses of breast implant capsules and how clinical risk factors impact the capsule morphology.
methodsThe literature search was conducted in PubMed. Studies that performed histological analyses of breast implant capsules were included. Animal studies or studies with a study population of less than five patients were excluded.
resultsFifty-two studies were included. The histological analyses showed that the breast implant capsules were organized in multiple layers with an inner layer of synovial-like metaplasia which was reported to diminish in capsules with capsular contracture. The remaining layers of the capsule mostly consisted of collagen. The alignment of the collagen fibers differed between contracted and non-contracted capsules, and capsules with higher Baker grade were generally thickest and contained more tissue inflammation. Studies investigating capsules affected by radiotherapy found a more pronounced inflammatory response and the capsules were generally thicker and fibrotic compared with nonirradiated capsules.
conclusionsThe included studies offer valuable insights into the histological changes caused by capsular contracture and their relation to clinical risk factors. Further studies with larger sample sizes and more strict inclusion criteria are needed to further investigate implant capsules and the role of the synovial-like metaplasia for the development of capsular contracture. LEVEL OF EVIDENCE III: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com/00266 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.