Trial reportNature immunology2021
Epigenetic scars of CD8
Abstract readClinical Trial, Phase III
In one paragraph
Trial report in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
173 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cure of chronic hepatitis C virus infection after DAA treatment only partially restores the functional capacity of exhausted T cell subsets: a systematic review.Frontiers in immunology · 2025Pooled it
- LAG3 checkpoint function and its mechanism of action in therapeutic targeting.Nature reviews. Immunology · 2026Review
- Article
- Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry.Current protocols · 2026Article
- Review
- Short-chain fatty acids act as metabolic and epigenetic regulators in CAR T cell therapy.Molecular therapy. Oncology · 2026Review
- Renaissance of antiviral CD8Nature reviews. Immunology · 2026Review
- Hepatitis C in the Direct-Acting Antiviral Era: Immunopathogenesis, Dendritic Cells and Modern Clinical Management.Biomedicines · 2026Review
- Enteric viral infections promote systemic accelerated aging inScience advances · 2026Article
- Therapeutic Vaccines for Chronic Viral Infections: From Immune Modulation to Clinical Translation.Vaccines · 2026Review
- Hallmarks and correlates of effective adoptive cell immunotherapy for cancer.Nature reviews. Immunology · 2026Review
- T Cell Exhaustion as a Regulated Differentiation Programme.European journal of immunology · 2026Review
- T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- MicroRNA-29a enhances and preserves stem-like CD8 T cell differentiation by regulating master epigenetic circuits of exhaustion.bioRxiv : the preprint server for biology · 2026Article
- Exhausted T cell phenotypes in disseminated coccidioidomycosis.JCI insight · 2026Article
- A Comprehensive Evaluation of CAR-T Cell Gene Therapy, Tracing its Revolutionary Clinical Breakthroughs and Advancements Towards Next-Generation Engineering.Expert reviews in molecular medicine · 2026Review
- T cell adaptation in chronic infections and tumors.Cellular & molecular immunology · 2026Review
- Circulating Tumor Cells Predict Response to the DLL3-Targeting Bispecific Antibody Tarlatamab.Cancer discovery · 2026Article
- Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions.Molecular biomedicine · 2026Review
- Clinical implications of residual changes following HCV clearance: Editorial on "Distinct inflammatory imprint in non-cirrhotic and cirrhotic patients before and after direct-acting antiviral therapy".Clinical and molecular hepatology · 2026Article
113 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Kathleen B YatesDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7383-5573
Pierre TonnerreDivision of Gastroenterology, Liver Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1719-9736
Genevieve E MartinNuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5142-7440
Ulrike GerdemannDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Rose Al AbosyDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5400-1306
Dawn E ComstockDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3718-8372
Sarah A WeissDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4155-0346
David WolskiDivision of Gastroenterology, Liver Center, Massachusetts General Hospital, Boston, MA, USA.
Damien C TullyRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7620-9340
Raymond T ChungDivision of Gastroenterology, Liver Center, Massachusetts General Hospital, Boston, MA, USA.
Todd M AllenRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6609-1318
Arthur Y KimDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
Sarah FidlerDivision of Medicine, Wright Fleming Institute, Imperial College, London, UK.
Julie FoxDepartment of Genitourinary Medicine and Infectious Disease, Guy's and St Thomas' NHS Foundation Trust, London, UK.
John FraterNuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7163-7277
Georg M LauerDivision of Gastroenterology, Liver Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9792-4271
W Nicholas Haining *Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. nick.haining@merck.com.ORCID http://orcid.org/0000-0001-7871-3762
Debattama R Sen *Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. dsen@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-0947-8284
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMedical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MVirology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG, GEORG Michael LAUER · 2009 to 2026
$48.1MResearch Training in Pediatric OncologyT32CA136432 · NCI · DANA-FARBER CANCER INST · PI SCOTT A ARMSTRONG · 2009 to 2026
$7.9MHIV, HCV, Hippo, and Liver Disease ProgressionR01AI136715 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, RAYMOND T · 2018 to 2022
$3.4MCancer Immunology Training GrantT32CA207021 · NCI · DANA-FARBER CANCER INST · PI WUCHERPFENNIG, KAI W · 2016 to 2020
$2.4MMedical Research Council MR/L00528X/1NCATS NIH HHS UL1 TR001863NCI NIH HHS T32 CA136432NCI NIH HHS T32 CA207021NIAID NIH HHS R01 AI136715NIAID NIH HHS U19 AI082630NIGMS NIH HHS T32 GM007753
Abstract
T cell exhaustion is an induced state of dysfunction that arises in response to chronic infection and cancer. Exhausted CD8
Indexed as
2-NaphthylamineAnilidesAntigens, ViralAntiviral AgentsCD8-Positive T-LymphocytesChromatinCyclopropanesEpigenesis, GeneticHepacivirusHepatitis C, ChronicHigh Mobility Group ProteinsHumansHypoxia-Inducible Factor 1, alpha SubunitImmunologic MemoryLactams, MacrocyclicProline2-NaphthylamineAnilidesAntigens, ViralAntiviral AgentsChromatinCyclopropanesdasabuvirHIF1A protein, humanHigh Mobility Group ProteinsHypoxia-Inducible Factor 1, alpha SubunitLactams, MacrocyclicombitasvirparitaprevirProlineRibavirinRitonavirSulfonamidesTOX protein, humanUracilValine
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.