ReviewNature reviews. Neurology2021
Headache in people with epilepsy.
Review in Nature reviews. Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Transcranial magnetic stimulation-evoked electroencephalography responses as biomarkers for epilepsy: A review of study design and outcomes.Human brain mapping · 2023Pooled it
- Chronic Physical Pain in Children With and Without Autism Spectrum Disorder in the United States: Findings from the 2016 - 2021 National Survey of Children's Health.Journal of autism and developmental disorders · 2026Article
- Dual role of spreading depolarization in an epileptic focus.Epilepsia · 2026Article
- Identification of common genetic and molecular signatures in migraine and comorbid conditions.The journal of headache and pain · 2026Review
- Associations among epilepsy phenotypes and pain, sleep interference, and dissociative symptoms.Rehabilitation psychology · 2026Article
- Distinct comorbidity phenotypes among post-9/11 Veterans with epilepsy are linked to diverging outcomes and mortality risks.Epilepsia · 2025Article
- Epilepsy and migraine: a diagnostic and therapeutic challenge.Frontiers in pharmacology · 2025Review
- Relationship between migraine and epilepsy in a large population-based cohort: The HUNT Study.European journal of neurology · 2024Article
- A cross-sectional, multicenter survey of the prevalence and influencing factors for migraine in epilepsy.Epilepsia open · 2024Article
- EEG Changes in Migraine-Can EEG Help to Monitor Attack Susceptibility?Brain sciences · 2024Review
- Migraine Prevalence, Environmental Risk, and Comorbidities in Men and Women Veterans.JAMA network open · 2024Article
- Migraine - a borderland disease to epilepsy: near it but not of it.The journal of headache and pain · 2024Review
- Astrocytes as critical players of the fine balance between inhibition and excitation in the brain: spreading depolarization as a mechanism to curb epileptic activity.Frontiers in network physiology · 2024Review
- Migraine and Epilepsy in Children: A Narrative Review of Comorbidity and Similar Treatment Option.Iranian journal of child neurology · 2024Review
- Neurovascular Compression-Induced Intracranial Allodynia May Be the True Nature of Migraine Headache: an Interpretative Review.Current pain and headache reports · 2023Review
- Genetic Mechanisms of Migraine: Insights from Monogenic Migraine Mutations.International journal of molecular sciences · 2023Review
- Sphingosine 1-phosphate receptor 1 regulates blood-brain barrier permeability in epileptic mice.Neural regeneration research · 2023Article
- Debate: differences and similarities between tension-type headache and migraine.The journal of headache and pain · 2023Review
- Global, regional, and national time trends in incidence for migraine, from 1990 to 2019: an age-period-cohort analysis for the GBD 2019.The journal of headache and pain · 2023Article
- Neuropeptide Y in the medial habenula alleviates migraine-like behaviors through the Y1 receptor.The journal of headache and pain · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological estimates indicate that individuals with epilepsy are more likely to experience headaches, including migraine, than individuals without epilepsy. Headaches can be temporally unrelated to seizures, or can occur before, during or after an episode; seizures and migraine attacks are mostly not temporally linked. The pathophysiological links between headaches (including migraine) and epilepsy are complex and have not yet been fully elucidated. Correct diagnoses and appropriate treatment of headaches in individuals with epilepsy is essential, as headaches can contribute substantially to disease burden. Here, we review the insights that have been made into the associations between headache and epilepsy over the past 5 years, including information on the pathophysiological mechanisms and genetic variants that link the two disorders. We also discuss the current best practice for the management of headaches co-occurring with epilepsy and highlight future challenges for this area of research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.