ArticleNature biotechnology2021
High-throughput mapping of a whole rhesus monkey brain at micrometer resolution.
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Article in Nature biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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76citing papers in PubMed
24.5field-weighted citation impact, top 1% of its field
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Who cites it
76 citing papers in PubMed, 140 citations in OpenAlex.
- A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions.Nature neuroscience · 2026Article
- Genetically Encoded Melanin as a Photostable Scattering Contrast for Whole-Brain Tomography.bioRxiv : the preprint server for biology · 2026Article
- Scaling up polarization-sensitive optical coherence tomography to image the whole macaque brain.bioRxiv : the preprint server for biology · 2026Article
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- An anatomical and connectivity atlas of the tree shrew brain to bridge rodent and primate neuroanatomy.PLoS biology · 2026Article
- vEMRec: High-Resolution Volume Electron Microscopy Reconstruction Based on Structure-Preserving and High-Fidelity 3D Alignment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Intravital mesoscale optical imaging: challenges, techniques, and future perspectives.Biophysics reports · 2026Article
- Fluorescent Labeling Methods for Brain Structure Research.Molecules (Basel, Switzerland) · 2026Review
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- Synaptic control of retinal ganglion cell survival and axon regeneration.Molecular neurodegeneration · 2026Review
- What needs to be standardized for reliable, reproducible, and robust tractography?GigaScience · 2026Review
- Grand challenges for systems neuroscience: perspectives and opportunities.Frontiers in systems neuroscience · 2026Article
- Reconstructing the human brain's wiring diagram from axons up.Trends in neurosciences · 2026Review
- Functional vs anatomical cortico-striatal connectivity in the macaque brain.Translational psychiatry · 2025Article
- High-resolution brain mapping with cytoarchitecture-based link estimation.Nature methods · 2025Article
- Whole-brain reconstruction of fiber tracts based on cytoarchitectonic organization.Nature methods · 2025Article
- Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning.Science (New York, N.Y.) · 2025Article
- Deconstruction of a spino-brain-spinal cord circuit drives chronic mechanical pain.Research square · 2025Article
- Automatic and accurate reconstruction of long-range axonal projections of single-neuron in mouse brain.eLife · 2025Article
- Advances in tissue optical clearing for 3D imaging in large animal.Frontiers of optoelectronics · 2025Review
16 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 8 institutions in 3 countries.
Fang Xu *Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0003-1458-9875
Yan Shen *CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, Hefei, China.
Lufeng Ding *CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, Hefei, China.
Chao-Yu Yang *CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, Hefei, China.
Heng TanKey Laboratory of Animal Models and Human Disease Mechanism, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Hao WangCenter for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, China.
Qingyuan ZhuCenter for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, China.
Rui XuMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8526-3392
Fengyi WuCAS Key Laboratory of Brain Connectome and Manipulation, Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Yanyang XiaoCAS Key Laboratory of Brain Connectome and Manipulation, Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.ORCID http://orcid.org/0000-0002-8284-5183
Cheng XuCenter for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, China.
Qianwei LiCenter for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, China.
Peng SuState Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China.
Li I ZhangZilkha Neurogenetic Institute, Center for Neural Circuits & Sensory Processing Disorders, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hong-Wei DongUCLA Brain Research & Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Robert DesimoneMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Fuqiang XuCAS Key Laboratory of Brain Connectome and Manipulation, Interdisciplinary Center for Brain Information, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Xintian HuKey Laboratory of Animal Models and Human Disease Mechanism, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.
Pak-Ming LauCenter for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, China. plau@ustc.edu.cn.ORCID http://orcid.org/0000-0001-9026-5501
Guo-Qiang BiCenter for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, and School of Life Sciences, University of Science and Technology of China, Hefei, China. gqbi@ustc.edu.cn.ORCID http://orcid.org/0000-0001-8735-3818
University of Science and Technology of China · CNKunming Institute of Zoology · CNMcGovern Institute for Brain Research · USShenzhen Institutes of Advanced Technology · CNCenter for Excellence in Brain Science and Intelligence Technology · CNChinese Academy of Sciences · CNUniversity of California, Los Angeles · USUniversity of Southern California · US
Funding
Cell atlas of mouse brain-spinal cord connectomeU01MH116990 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DONG, HONG-WEI, TAO, HUIZHONG WHIT · 2018 to 2022
$12.0MNIMH NIH HHS U01 MH116990
Abstract
Whole-brain mesoscale mapping in primates has been hindered by large brain sizes and the relatively low throughput of available microscopy methods. Here, we present an approach that combines primate-optimized tissue sectioning and clearing with ultrahigh-speed fluorescence microscopy implementing improved volumetric imaging with synchronized on-the-fly-scan and readout technique, and is capable of completing whole-brain imaging of a rhesus monkey at 1 × 1 × 2.5 µm
Indexed as
BrainBrain MappingAnimalsImaging, Three-DimensionalMacaca mulatta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.