ArticleNature plants2021
Active suppression of leaflet emergence as a mechanism of simple leaf development.
Article in Nature plants, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 53 citations in OpenAlex.
- New components in genetic regulation of age-dependent compound leaf architecture in pea.The New phytologist · 2026Article
- Growth-rate coordination across the width of a leaf preserves its flatness.PLoS biology · 2026Article
- Morphogenesis of moss leaf-like organs through variations in deeply shared developmental principles.Science advances · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- Transcriptomic and biochemical analyses revealed the dynamic regulatory mechanisms underlying leaf morphogenesis inFrontiers in plant science · 2026Article
- Big data approaches to understanding gene regulatory networks in the shoot apical meristem andFrontiers in plant science · 2026Review
- Multi-dimensional regulation of tea leaf development: morphogenesis, hormone-transcriptional networks, environmental factors, and artificial cultivation practices.Frontiers in plant science · 2026Review
- TCP3-mediated regulation of cell expansion in Arabidopsis thaliana.The New phytologist · 2025Article
- Homeodomain transcription factor regulation of leaf serrations in Arabidopsis thaliana.Journal of experimental botany · 2025Article
- The F-box protein RCN127 enhances rice tillering and grain yield by mediating the degradation of OsTB1 and OsTCP19.Plant biotechnology journal · 2025Article
- Regulation of meristem and hormone function revealed through analysis of directly-regulated SHOOT MERISTEMLESS target genes.Scientific reports · 2025Article
- Modulation of cell differentiation and growth underlies the shift from bud protection to light capture in cauline leaves.Plant physiology · 2024Article
- Fine-mapping of a major QTL controlling plant height by BSA-seq and transcriptome sequencing in cotton.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A distinct foliar pigmentation pattern formed by activator-repressor gradients upstream of an anthocyanin-activating R2R3-MYB.Cell reports · 2024Article
- Shaping leaves through TALE homeodomain transcription factors.Journal of experimental botany · 2024Review
- GRAS transcription factor PINNATE-LIKE PENTAFOLIATA2 controls compound leaf morphogenesis in Medicago truncatula.The Plant cell · 2024Article
- Rewiring of a KNOXI regulatory network mediated by UFO underlies the compound leaf development in Medicago truncatula.Nature communications · 2024Article
- Control of compound leaf patterning by MULTI-PINNATE LEAF1 (MPL1) in chickpea.Nature communications · 2023Article
- A double-negative feedback loop between miR319c and JAW-TCPs establishes growth pattern in incipient leaf primordia in Arabidopsis thaliana.PLoS genetics · 2023Article
- DNA barcoding and comparative RNA-Seq analysis provide new insights into leaf formation using a novel resource of high-yieldingFrontiers in plant science · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiosperm leaves show extensive shape diversity and are broadly divided into two forms; simple leaves with intact lamina and compound leaves with lamina dissected into leaflets. The mechanistic basis of margin dissection and leaflet initiation has been inferred primarily by analysing compound-leaf architecture, and thus whether the intact lamina of simple leaves has the potential to initiate leaflets upon endogenous gene inactivation remains unclear. Here, we show that the CINCINNATA-like TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORS (CIN-TCP) transcription factors activate the class II KNOTTED1-LIKE (KNOX-II) genes and the CIN-TCP and KNOX-II proteins together redundantly suppress leaflet initiation in simple leaves. Simultaneous downregulation of CIN-TCP and KNOX-II in Arabidopsis leads to the reactivation of the stemness genes KNOX-I and CUPSHAPED COTYLEDON (CUC) and triggers ectopic organogenesis, eventually converting the simple lamina to a super-compound form that appears to initiate leaflets indefinitely. Thus, a conserved developmental mechanism promotes simple leaf architecture in which CIN-TCP-KNOX-II forms a strong differentiation module that suppresses the KNOX-I-CUC network and leaflet initiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.