ArticleScientific reports2021
Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Microvascular Dropout Within the Lamina Cribrosa in Myopic Eyes With a Parapapillary γ-Zone and Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2026Article
- Relationship Between Parapapillary Microvasculature Dropout and Visual Field Defect in Glaucoma: A Cross-Sectional OCTA Analysis.Journal of clinical medicine · 2025Article
- Choroidal microvascular dropout and its relationship to progression in primary open-angle and pseudoexfoliation glaucoma.BMC ophthalmology · 2025Article
- Comparative analysis of the optic nerve microvasculature between different optic disc phenotypes of normal-tension glaucoma patients.BMC ophthalmology · 2025Article
- Underlying Microstructure of the Lamina Cribrosa at the Site of Microvasculature Dropout.Investigative ophthalmology & visual science · 2024Article
- Temporal Optic Disc Microvasculature Dropout in Glaucoma.Investigative ophthalmology & visual science · 2023Article
- Reduced intradisc vessel density is associated with optic disc hemorrhage in eyes with primary open-angle glaucoma.Scientific reports · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of parapapillary choroidal microvasculature dropout (CMvD) may affect optic nerve head (ONH) perfusion in glaucoma patients, since parapapillary choroidal vessels provide vascular supply to the neighboring ONH. However, it remains to be determined whether the presence of parapapillary CMvD is associated with diminished perfusion in the nearby ONH. The present study investigated the spatial relationship between CMvD and ONH vessel density (ONH-VD) loss in open-angle glaucoma (OAG) eyes using optical coherence tomography angiography (OCT-A). This study included 48 OAG eyes with a single localized CMvD confined to the inferotemporal parapapillary sector and 48 OAG eyes without CMvD, matched for demographic and ocular characteristics. Global and regional ONH-VD values were compared between eyes with and without CMvD. The relationships between ONH-VD outcomes and clinical variables were assessed. ONH-VDs at the inferotemporal ONH sectors corresponding to the CMvD location were significantly lower in eyes with compared to those without CMvD. Multivariable linear regression analyses indicated that a lower inferotemporal ONH-VD was independently associated with CMvD presence and a greater CMvD angular extent (both P < 0.05). The localized presence of parapapillary CMvD in OAG eyes is significantly associated with ONH-VD loss in the neighboring ONH location, with a spatial correlation.
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