Evidence map›Paper›PMID 34312441›Full record

ArticleScientific reports2021

An ultra-portable, self-contained point-of-care nucleic acid amplification test for diagnosis of active COVID-19 infection.

Hao Deng, Asanka Jayawardena, Jianxiong Chan, Sher Maine Tan, Tuncay Alan, Patrick Kwan

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hao Deng *Department of Mechanical and Aerospace Engineering, Monash University, Clayton, VIC, 3800, Australia.
Asanka Jayawardena *Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.
Jianxiong Chan *Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.
Sher Maine TanDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.
Tuncay AlanDepartment of Mechanical and Aerospace Engineering, Monash University, Clayton, VIC, 3800, Australia. tuncay.alan@monash.edu.
Patrick KwanDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia. patrick.kwan@monash.edu.
Monash University · AU

Funding

Medical Research Future Fund Fellowship MRF113642
6 · The paper itself

Abstract

There is currently a high level of demand for rapid COVID-19 tests, that can detect the onset of the disease at point of care settings. We have developed an ultra-portable, self-contained, point-of-care nucleic acid amplification test for diagnosis of active COVID-19 infection, based on the principle of loop mediated isothermal amplification (LAMP). The LAMP assay is 100% sensitive and specific to detect a minimum of 300 RNA copies/reaction of SARS-CoV-2. All of the required sample transportation, lysing and amplification steps are performed in a standalone disposable cartridge, which is controlled by a battery operated, pocket size (6x9x4cm

Indexed as

Point-of-Care TestingCOVID-19COVID-19 Nucleic Acid TestingEquipment DesignHumansMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesRNA, ViralSARS-CoV-2Sensitivity and SpecificityTime FactorsRNA, Viral

Identifiers

PMID34312441
PMCPMC8313664
OpenAlexW3127615546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.