ArticleScientific reports2021
Impact of anticoagulation and antiplatelet drugs on surgery rates and mortality in trauma patients.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Transfusion and mortality after major trauma in patients on direct oral anticoagulants: a multicentre cohort study.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Effects of different intraoperative warming strategies on hypothermia and postoperative coagulation function in severely injured emergency surgery patients.Frontiers in medicine · 2026Article
- Article
- Oral anticoagulant reversal and mortality in trauma patients: a multicentre propensity score-matched cohort study.EClinicalMedicine · 2025Article
- Management of factor Xa inhibitor-related traumatic non-intracranial bleeding events with andexanet alfa or four-factor prothrombin complex concentrate in a US multicenter observational study.Journal of the American College of Emergency Physicians open · 2024Article
- Article
- Early Hip Fracture Surgery in Patients Taking Direct Oral Anticoagulants Improves Outcome.Journal of clinical medicine · 2024Article
- Bilateral simultaneous knee arthroplasty shows comparable early outcome and complication rate as staged bilateral knee arthroplasty for patients scored ASA 1-3 if performed by a high-volume surgeon: a retrospective cohort study of 127 cases.Archives of orthopaedic and trauma surgery · 2024Article
- Is It Safe to Resume Direct Oral Anticoagulants upon Discharge after Hip Fracture Surgery? A Retrospective Study.Journal of clinical medicine · 2023Article
- Outcomes of trauma patients on chronic antithrombotic therapies in a trauma center in a rural state.Surgery in practice and science · 2023Article
- Treatment and outcomes of anticoagulated geriatric trauma patients with traumatic intracranial hemorrhage after falls.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Does Antithrombotic Therapy Affect Outcomes in Major Trauma Patients? A Retrospective Cohort Study from a Tertiary Trauma Centre.Journal of clinical medicine · 2022Article
- Retrospective cohort study to determine the effect of preinjury antiplatelet or anticoagulant therapy on mortality in patients with major trauma.Frontiers in medicine · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preinjury anticoagulation therapy (AT) is associated with a higher risk for major bleeding. We aimed to evaluated the influence of preinjury anticoagulant medication on the clinical course after moderate and severe trauma. Patients in the TraumaRegister DGU ≥ 55 years who received AT were matched with patients not receiving AT. Pairs were grouped according to the drug used: Antiplatelet drugs (APD), vitamin K antagonists (VKA) and direct oral anticoagulants (DOAC). The primary end points were early (< 24 h) and total in-hospital mortality. Secondary endpoints included emergency surgical procedure rates and surgery rates. The APD group matched 1759 pairs, the VKA group 677 pairs, and the DOAC group 437 pairs. Surgery rates were statistically significant higher in the AT groups compared to controls (APD group: 51.8% vs. 47.8%, p = 0.015; VKA group: 52.4% vs. 44.8%, p = 0.005; DOAC group: 52.6% vs. 41.0%, p = 0.001). Patients on VKA had higher total in-hospital mortality (23.9% vs. 19.5%, p = 0.026), whereas APD patients showed a significantly higher early mortality compared to controls (5.3% vs. 3.5%, p = 0.011). Standard operating procedures should be developed to avoid lethal under-triage. Further studies should focus on detailed information about complications, secondary surgical procedures and preventable risk factors in relation to mortality.
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