ArticleGut and liver2022
Impact of Visceral Fat on Survival and Metastasis of Stage III Colorectal Cancer.
Article in Gut and liver, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Systematic review: The gut microbiota as a link between colorectal cancer and obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- Development and external validation of a preoperative CT body composition-based model for predicting postoperative metastasis in colorectal cancer: a multicenter retrospective cohort study.Abdominal radiology (New York) · 2026Article
- Subcutaneous adipose tissue loss as an early indicator of cancer cachexia in unresectable pancreatic cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- CT-based abdominal fat parameters as predictors of recurrence-free survival after radical resection of colorectal cancer: a nomogram approach.Abdominal radiology (New York) · 2026Article
- Preoperative CT-derived liver fat fraction and visceral adipose tissue index enhance postoperative recurrence risk stratification in colorectal cancer.Frontiers in oncology · 2026Article
- Association of preoperative CT-derived visceral adipose tissue index with synchronous metastasis and metastasis-free survival after curative-intent surgery in colorectal cancer.Frontiers in oncology · 2026Article
- Preoperative CT deep learning of tumor and visceral adipose tissue combined with postoperative pathology predicts colorectal cancer recurrence: a multicenter study.Frontiers in molecular biosciences · 2026Article
- Correlation between peritumoral fat space blur on preoperative abdominal enhanced CT and postoperative complications in colorectal cancer: a single-center retrospective study.American journal of translational research · 2026Article
- Multimodal deep learning: tumor and visceral fat impact on colorectal cancer occult peritoneal metastasis.European radiology · 2025Article
- Visceral adipose tissue is associated with occult synchronous peritoneal metastasis in colorectal cancer.Pleura and peritoneum · 2025Article
- Synergic value of 3D CT-derived body composition and triglyceride glucose body mass for survival prognostic modeling in unresectable pancreatic cancer.Frontiers in nutrition · 2025Article
- Predicting 3-year all-cause mortality in rectal cancer patients based on body composition and machine learning.Frontiers in nutrition · 2025Article
- Association between muscle mass and overall survival among colorectal cancer patients at tertiary cancer center in the Middle East.Scientific reports · 2024Article
- The Role of Adipocytes Recruited as Part of Tumor Microenvironment in Promoting Colorectal Cancer Metastases.International journal of molecular sciences · 2024Review
- Age-adjusted Charlson comorbidity index and its association with body composition and overall survival in patients with colorectal cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- The role of sarcopenic obesity for the prediction of prognosis of patients with gastrointestinal cancer.Cancer medicine · 2024Article
- Change in abdominal obesity after colon cancer surgery - effects of left-sided and right-sided colonic resection.International journal of obesity (2005) · 2024Article
- Visceral Obesity and a High Glasgow Prognostic Score Are Key Prognostic Factors for Metastatic Colorectal Cancer Treated with First Line Chemotherapy.Journal of the anus, rectum and colon · 2024Article
- Body composition: a crucial factor in downstaging and postoperative complications of neoadjuvant chemotherapy for gastric cancer.Frontiers in nutrition · 2024Article
- Computed tomography-measured body composition can predict long-term outcomes for stage I-III colorectal cancer patients.Frontiers in oncology · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsPrevious studies have investigated the relationship between visceral obesity and the risk of colorectal tumors. Visceral obesity may affect the outcome of colorectal cancer (CRC), including survival and metastasis. We investigated the associations between visceral adipose tissue and oncologic outcomes in stage III CRC.
methodsFour hundred seventy-two patients with stage III CRC were identified. Subcutaneous and visceral adipose tissue areas were measured volumetrically via computed tomography for each patient at different levels of the lumbar spine. After adjusting for age, sex, and other clinical factors, the effects of visceral adipose tissue area on mortality and recurrence were assessed using Cox proportional hazard regression.
resultsIn univariate and multivariate analyses, a higher visceral adipose tissue to total adipose tissue (VT) ratio (hazard ratio [HR], 1.041; 95% CI, 1.008 to 1.075; p=0.015) and higher visceral adipose tissue to subcutaneous adipose tissue (VS) ratio (HR, 1.016; 95% CI, 1.005 to 1.028; p=0.006) were both associated with poor CRC-specific survival. Interestingly, in the evaluation of each site of recurrence, a higher VT ratio (HR, 1.069; 95% CI, 1.010 to 1.131; p=0.020) and higher VS ratio (HR, 1.024; 95% CI, 1.003 to 1.045; p=0.023) were both related to a higher risk of peritoneal seeding and tumor recurrence. The VT ratio at the L3-L4 level was significantly associated with a higher risk of peritoneal seeding and tumor recurrence (HR, 4.969; 95% CI, 1.303 to 18.949; p=0.019), while other levels showed no such relationship.
conclusionsVisceral obesity is closely related to increased risks of CRC-specific mortality and peritoneal seeding metastasis in stage III CRC patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.