Evidence map›Paper›PMID 34312250›Full record

ReviewCold Spring Harbor perspectives in biology2022

Insect Gut Regeneration.

Peng Zhang, Bruce A Edgar

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Evidence that injury can causebioRxiv : the preprint server for biology · 2026
    Article
  6. Molecules (Basel, Switzerland) · 2025
    Article
  7. Drosophila Intestine as a Model to Study Tumors.Advances in experimental medicine and biology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Trametinib ameliorates aging-associated gut pathology inProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  14. Review
  15. Frontiers in cell and developmental biology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Peng ZhangHuntsman Cancer Institute, University of Utah.
Bruce A EdgarHuntsman Cancer Institute, University of Utah.
Huntsman Cancer Institute · USUniversity of Utah · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6M
REGULATION OF CELL GROWTH AND PROLIFERATIONR35GM140900 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Bruce Alexander Edgar · 2021 to 2026
$4.5M
Sex steroid signaling and adaptive growth of the intestineR01DK125745 · NIDDK · UNIVERSITY OF UTAH · PI EDGAR, BRUCE ALEXANDER · 2021 to 2024
$1.9M
Damage Sensing and Growth Control in the Drosophila GutR01GM124434 · NIGMS · UNIVERSITY OF UTAH · PI EDGAR, BRUCE ALEXANDER · 2017 to 2020
$1.7M
Translational Control of Cell ProliferationR01GM126033 · NIGMS · UNIVERSITY OF UTAH · PI EDGAR, BRUCE ALEXANDER · 2018 to 2020
$1.3M
NCI NIH HHS P30 CA042014NIDDK NIH HHS R01 DK125745NIGMS NIH HHS R01 GM124434NIGMS NIH HHS R01 GM126033NIGMS NIH HHS R35 GM140900
6 · The paper itself

Abstract

In adult insects, as in vertebrates, the gut epithelium is a highly regenerative tissue that can renew itself rapidly in response to changing inputs from nutrition, the gut microbiota, ingested toxins, and signals from other organs. Because of its cellular and genetic similarities to the mammalian intestine, and its relevance as a target for the control of insect pests and disease vectors, many researchers have used insect intestines to address fundamental questions about stem cell functions during tissue maintenance and regeneration. In

Indexed as

DrosophilaDrosophila ProteinsAnimalsCell ProliferationEnterocytesIntestinesMammalsStem CellsDrosophila Proteins

Identifiers

PMID34312250
PMCPMC8805648
OpenAlexW3184495183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.