Evidence map›Paper›PMID 34311938›Full record

ArticleVeterinary parasitology2019

Trypanosoma vivax infection in sheep: Different patterns of virulence and pathogenicity associated with differentially expressed proteomes.

Roger Ramirez-Barrios, Armando Reyna-Bello, Omaira Parra, Robert Valeris, Lucinda Tavares-Marques, Jean-Paul Brizard, Edith Demettre, Martial Seveno, Alvaro Martinez-Moreno, Philippe Holzmuller

Abstract read
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In one paragraph

Article in Veterinary parasitology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Roles of cytokines in modulatingFrontiers in parasitology · 2025
    Article
  2. Review
4 · The record

Corrections and comments

  • Reprint of
    2019
5 · Who and what money

Authors and funding

10 authors.

Roger Ramirez-BarriosLaboratorio de Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad del Zulia, Maracaibo, Venezuela. Electronic address: rramirez@d.umn.edu.
Armando Reyna-BelloLaboratorio de Inmunobiología, Centro de Estudios Biomédicos y Veterinarios, Universidad Nacional Experimental Simón Rodríguez, Caracas, Venezuela.
Omaira ParraLaboratorio de Enfermedades Parasitarias, Facultad de Ciencias Veterinarias, Universidad del Zulia, Maracaibo, Venezuela.
Robert ValerisLaboratorio de Infectología Veterinaria, Facultad de Ciencias Veterinarias, Universidad del Zulia, Maracaibo, Venezuela.
Lucinda Tavares-MarquesLaboratorio de Inmunobiología, Centro de Estudios Biomédicos y Veterinarios, Universidad Nacional Experimental Simón Rodríguez, Caracas, Venezuela.
Jean-Paul BrizardIRD, CIRAD, Univ. Montpellier (I-MUSE), Interactions Plantes Microorganismes et Environnement (IPME), Montpellier, France.
Edith DemettreBioCampus Montpellier, CNRS, INSERM, Univ. Montpellier, Montpellier, France.
Martial SevenoBioCampus Montpellier, CNRS, INSERM, Univ. Montpellier, Montpellier, France.
Alvaro Martinez-MorenoDepartamento de Sanidad Animal, Universidad de Córdoba, España.
Philippe HolzmullerCIRAD, UMR ASTRE, F-34398 Montpellier, France; ASTRE, CIRAD, INRA, Univ. Montpellier (I-MUSE), Montpellier, France; INTERTRYP, CIRAD, IRD, Univ. Montpellier (I-MUSE), Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cattle trypanosomosis caused by Trypanosoma vivax is a widely distributed disease in Africa and Latin America. It causes significant losses in the livestock industry and is characterized by fluctuating parasitemia, anemia, fever, lethargy, and weight loss. In this study we evaluated the virulence (capacity to multiply inside the host and to modulate the host response) and pathogenicity (ability to produce disease and/or mortality) patterns of two T. vivax strains (TvMT1 and TvLIEM176) in experimentally-infected sheep and determined the proteins differentially expressed in the proteomes of these two strains. Hematological and clinical parameters were monitored in experimentally-infected versus non-infected sheep for 60 days. All the infected animals developed discernable parasitemia at 3 days post-infection (dpi), and the first parasitemia peak was observed at 6 dpi. The maximum average value of parasitemia was 1.3×10

Indexed as

BiomarkersPathogenicityProteomicsTrypanosoma vivaxVirulence

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.