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ArticleVeterinary parasitology2019

Efficacy of an injectable toltrazuril - gleptoferron (Forceris®) to control coccidiosis (Cystoisospora suis) in comparison with iron supplemented piglets without anticoccidial treatment.

Lysanne Hiob, Ivette Holzhausen, Daniel Sperling, Gaëlle Pagny, Laurianne Meppiel, Naomi Isaka, Arwid Daugschies

Abstract read
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In one paragraph

Article in Veterinary parasitology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Lysanne HiobAlbrecht - Daniel - Thaer - Institute for Agricultural Sciences e.V. at University of Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany; Institute of Parasitology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 35, 04103 Leipzig, Germany. Electronic address: lysanne.hiob@vetmed.uni-leipzig.de.
Ivette HolzhausenAlbrecht - Daniel - Thaer - Institute for Agricultural Sciences e.V. at University of Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany; Institute of Parasitology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 35, 04103 Leipzig, Germany.
Daniel SperlingCEVA Santé Animale, 10 avenue de la Ballastière, 33500 Libourne, France.
Gaëlle PagnyCEVA Santé Animale, 10 avenue de la Ballastière, 33500 Libourne, France.
Laurianne MeppielCEVA Santé Animale, 10 avenue de la Ballastière, 33500 Libourne, France.
Naomi IsakaCEVA Santé Animale, 10 avenue de la Ballastière, 33500 Libourne, France.
Arwid DaugschiesAlbrecht - Daniel - Thaer - Institute for Agricultural Sciences e.V. at University of Leipzig, An den Tierkliniken 29, 04103 Leipzig, Germany; Institute of Parasitology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 35, 04103 Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy and safety of an injectable combination product containing toltrazuril and gleptoferron (Forceris® - CEVA) for the control of coccidiosis due to Cystoisospora suis was investigated in neonatal piglets. The study was carried out on five European commercial pig farms in France, Germany and Spain and 122 litters consisting of 1508 piglets were selected and randomly allocated to one of two treatment groups. The first group received a single intramuscular injection per piglet of the test product, containing 45 mg toltrazuril and 200 mg iron and this was compared with a control group, which was administered a single intramuscular treatment of iron at 200 mg per piglet only. Body weights, faecal scores and oocysts counts, recorded as oocysts per gram of faeces, (OPG) were observed for 21 days. Only 1138 piglets were actually exposed to coccidiosis and data sets of these animals were selected for statistical analysis. The efficacy of the test product in the control of coccidiosis was shown in higher body weight gains, a lower percentage of animals with diarrhoea, fewer samples with positive oocysts counts as well as a lower excretion peak and a reduced area under the curve of OPG from study day (SD) 4 - SD 21. The combination product of toltrazuril and gleptoferron provided an effective alternative approach to current conventional separate treatment for the prevention of iron deficiency anaemia and coccidiosis in neonatal piglets. It reduced the numbers of potentially stressful interventions and work time.

Indexed as

CoccidiosisCystoisospora suisDiarrhoeaForceris®Natural infectionPigletToltrazuril

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.