Evidence map›Paper›PMID 34311780›Full record

ReviewGenome medicine2021

We need to bring R0 < 1 to treat cancer too.

Devabhaktuni Srikrishna, Kris Sachsenmeier

Open access · goldAbstract readReview
In one paragraph

Review in Genome medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Devabhaktuni SrikrishnaBreakbio Corp., 63 Bovet Road, #418, San Mateo, CA, 94402, USA. sri.devabhaktuni@gmail.com.ORCID 0000-0002-5927-3623
Kris SachsenmeierTranslational Medicine-Oncology, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, USA.
AstraZeneca (United States) · USGoPro (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

If each cancer cell produces on average more than one cancer cell, we see a net growth of the tumors and metastases and vice versa. We review recent clinical results for microsatellite stable metastatic colorectal cancer (MSS-mCRC) suggesting immunotherapy combinations with personalized vaccines, checkpoint inhibitors, targeted therapies, multikinase inhibitors, chemotherapies, and radiation that simultaneously slow cancer cell growth rate and enhance T cell killing rate of cancer cells may in future synergize to control the disease.

Indexed as

Disease ManagementDisease SusceptibilityModels, TheoreticalBiomarkers, TumorCombined Modality TherapyHumansImmunotherapyMicrosatellite InstabilityNeoplasm MetastasisNeoplasmsNeoplasm StagingT-LymphocytesTumor MicroenvironmentBiomarkers, Tumor

Identifiers

PMID34311780
PMCPMC8312206
OpenAlexW3186924472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.