Evidence map›Paper›PMID 34311703›Full record

Observational studyBMC infectious diseases2021

Lower urinary tract signs and symptoms in patients with COVID-19.

Aida Javan Balegh Marand, Christian Bach, Dick Janssen, John Heesakkers, Morteza Ghojazadeh, Thomas Alexander Vögeli, Hanieh Salehi-Pourmehr, Hadi Mostafae, Sakineh Hajebrahimi, Mohammad Sajjad Rahnama'i

Open access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

  1. Longitudinal Evaluation of Lower Urinary Tract Symptoms up to Six Months after COVID-19 Infection in a Jordanian Cohort.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2025
    Article
  2. Article
  3. Review
  4. The Effect of Covid-19 Severity on Lower Urinary Tract Symptoms Manifestations.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Aida Javan Balegh MarandUniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Christian BachUniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Dick JanssenRadboud University, Nijmegen, The Netherlands.
John HeesakkersRadboud University, Nijmegen, The Netherlands.
Morteza GhojazadehResearch Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Thomas Alexander VögeliUniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
Hanieh Salehi-PourmehrResearch Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Hadi MostafaeMedical University of Vienna, Tabriz, Austria.
Sakineh HajebrahimiResearch Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Sajjad Rahnama'iUniklinik RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany. sajjad_r@yahoo.com.ORCID http://orcid.org/0000-0003-1953-7441
Radboud University Nijmegen · NLTabriz University of Medical Sciences · IRUniversitätsklinikum Aachen · DEMedical University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe type of pneumonia that is caused by the new coronavirus (SARS-CoV-2) has spread across the world in a pandemic. It is not clear if COVID-19 patients have any lower urinary tract signs or symptoms.

methodsThe effect of COVID-19 on lower urinary tract function was studied in a prospective multi-centre, observational study including 238 patients who were admitted with symptoms caused by COVID-19 to the university hospital of Aachen in Germany and Tabriz in Iran.

resultsNone of the patients reported to have any lower urinary tract symptoms. SARS-CoV-2 was found in the urine of 19% of the tested patients. The mortality rate in COVID-19 infected patients with microscopic haematuria together with white blood cells in their urine, was significantly increased from 48 to 61% in the Tabriz cohort (p-value = 0.03) and from 30 to 35% in the Aachen cohort (p-value =0.045). Furthermore, in the group of patients with SARS-CoV-2 urine PCR, the mortality rate rose from 30 to 58%. (p-value =0.039).

conclusionPatients admitted with COVID-19 did not report to have any lower urinary tract symptoms, even those patient who had a positive Urine SARS-CoV-2 PCR. In addition, hematuria, WBC in urine as well as SARS- CoV-2 presence in urine, were found to be strong negative prognostic factors in admitted COVID-19 patients.

Indexed as

COVID-19Urinary TractHumansPandemicsProspective StudiesSARS-CoV-2COVID-19HematuriaLower urinary tract symptoms (LUTS)SARS-CoV-2Urine, leukocyturia

Identifiers

PMID34311703
PMCPMC8312200
OpenAlexW3185110934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.