Evidence map›Paper›PMID 34311624›Full record

ArticleJournal of investigative medicine high impact case reports

Incidental Finding of Squamous Cell Carcinoma on a 68Ga-DOTATATE PET Scan.

Sanjana Mullangi, Manidhar Reddy Lekkala, Charumathi Raghu Subramanian, Omar Nemer, Jagmeet Singh, Asim Kichloo, Bahar Moftakhar

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sanjana MullangiHillcrest Medical Center, Tulsa, OK, USA.
Manidhar Reddy LekkalaUniversity of Rochester Medical Center, Rochester, NY, USA.ORCID 0000-0003-3302-1855
Charumathi Raghu SubramanianUniversity of California San Francisco, CA, USA.
Omar NemerUniversity of Rochester Medical Center, Rochester, NY, USA.
Jagmeet SinghGeisinger Commonwealth School of Medicine, Scranton, PA, USA.
Asim KichlooCMU Medical Education Partners, Saginaw, MI, USA.ORCID 0000-0003-4788-8572
Bahar MoftakharUniversity of Rochester Medical Center, Rochester, NY, USA.
University of Rochester Medical Center · USGeisinger Commonwealth School of Medicine · USHillcrest Hospital · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine tumors (NETs) are a relatively rare entity; however, the incidence and prevalence of these tumors are increasing, likely attributed to improved diagnostic accuracy. The diagnosis of suspected NETs is facilitated by clinical symptoms, laboratory test abnormalities such as elevated chromogranin-A, and other diagnostic modalities such as the use of computed tomography scans, magnetic resonance imaging scans, positron emission tomography (PET) scans, and biopsy. The expression of high levels of somatostatin receptors in NETs enables the use of a specialized PET scan using the radiolabeled somatostatin analogues 68Ga-DOTATATE. The sensitivity and specificity of 68Ga-DOTATATE PET is very high for the diagnosis of NETs, but the specificity decreases especially with no clear symptoms and with only borderline elevated tumor markers. We present a case of a suspected NET, which was initially diagnosed as a metastatic NET by virtue of a positive 68Ga-DOTATATE PET scan; however, on biopsy it was revealed to be a squamous cell carcinoma originating from the head and neck.

Indexed as

Carcinoma, Squamous CellNeuroendocrine TumorsOrganometallic CompoundsHumansIncidental FindingsPositron-Emission Tomographygallium Ga 68 dotatateOrganometallic CompoundsNETneuroendocrine tumoroncologyPET DOTATATEsquamous cell carcinoma

Identifiers

PMID34311624
PMCPMC8320555
OpenAlexW3183858377

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.