Evidence map›Paper›PMID 34311584›Full record

ArticlemBio2021

Discovery of a Diverse Set of Bacteria That Build Their Cell Walls without the Canonical Peptidoglycan Polymerase aPBP.

Sharanjeet Atwal, Suthida Chuenklin, Edward M Bonder, Juan Flores, Joseph J Gillespie, Timothy P Driscoll, Jeanne Salje

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 40 citations in OpenAlex.

  1. Tick cells as a tractable arthropod model for studyingApplied and environmental microbiology · 2026
    Article
  2. Article
  3. Article
  4. Peptidoglycan polymerase function and regulation.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  5. Article
  6. Article
  7. PathogenicJournal of bacteriology · 2024
    Review
  8. Frontiers in microbiology · 2024
    Article
  9. Article
  10. mSphere · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. bioRxiv : the preprint server for biology · 2023
    Article
  15. Article
  16. Plasticity in the cell division processes of obligate intracellular bacteria.Frontiers in cellular and infection microbiology · 2023
    Review
  17. A highly divergentProceedings. Biological sciences · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Sharanjeet AtwalPublic Health Research Institute, Rutgers University, Newark, New Jersey, USA.
Suthida ChuenklinPublic Health Research Institute, Rutgers University, Newark, New Jersey, USA.
Edward M BonderDepartment of Biological Sciences, Rutgers University, Newark, New Jersey, USA.
Juan FloresDepartment of Biological Sciences, Rutgers University, Newark, New Jersey, USA.
Joseph J GillespieDepartment of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Timothy P DriscollDepartment of Biology, West Virginia University, Morgantown, West Virginia, USA.
Jeanne SaljePublic Health Research Institute, Rutgers University, Newark, New Jersey, USA.
Rutgers, The State University of New Jersey · USUniversity of Maryland, Baltimore · USWest Virginia University · US

Funding

INTERSPECIFIC COMPETITION BETWEEN RICKETTSIAE IN TICKSR01AI043006 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI AZAD, ABDU F · 1998 to 2014
$3.3M
Peptide-vaccine development against Lyme disease SupplementR01AI152219 · NIAID · WEST VIRGINIA UNIVERSITY · PI BARBIER, MARIETTE · 2020 to 2024
$2.1M
Metabolic quiescence and latent infection in Orientia tsutsugamushiR56AI148645 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI SALJE, JEANNE · 2020 to 2020
$471k
Characterizing the Pan-genome of a Rickettsia Infecting the Eastern Black-legged TickR21AI156762 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DRISCOLL, TIMOTHY P, GILLESPIE, JOSEPH J · 2021 to 2022
$435k
The basis of strain-specific differences in virulence in the human pathogen Orientia tsutsugamushiR21AI144385 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI SALJE, JEANNE · 2020 to 2021
$430k
Rickettsia cell envelope glycoconjugates are derived from the host cell amino sugar biosynthesis pathwayR21AI146773 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI GILLESPIE, JOSEPH J, RAHMAN, MOHAMMED SAYEEDUR · 2019 to 2020
$425k
Understanding the mechanism of 4-1BB costimulationR21AI052108 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI VELLA, ANTHONY T. · 2002 to 2002
$326k
NIAID NIH HHS R01 AI043006NIAID NIH HHS R01 AI152219NIAID NIH HHS R21 AI052108NIAID NIH HHS R21 AI144385NIAID NIH HHS R21 AI146773NIAID NIH HHS R21 AI156762NIAID NIH HHS R56 AI148645Wellcome TrustWellcome Trust 220211
6 · The paper itself

Abstract

Peptidoglycan (PG) is a highly cross-linked peptide-glycan mesh that confers structural rigidity and shape to most bacterial cells. Polymerization of new PG is usually achieved by the concerted activity of two membrane-bound machineries, class-A penicillin binding proteins (aPBPs) and class-B penicillin binding proteins (bPBPs) in complex with shape, elongation, division, and sporulation (SEDS) proteins. Here, we have identified four phylogenetically distinct groups of bacteria that lack any identifiable aPBPs. We performed experiments on a panel of species within one of these groups, the

Indexed as

Bacterial ProteinsBiosynthetic PathwaysCell DivisionCell WallHumansPenicillin-Binding ProteinsPeptidoglycanRickettsiaceaeBacterial ProteinsPenicillin-Binding ProteinsPeptidoglycanendosymbiontsGram-negative bacteriahost-pathogen interactionsobligate intracellular bacteriaorthogonal chemical probespenicillin binding proteinspeptidoglycanRickettsiales

Identifiers

PMID34311584
PMCPMC8406291
OpenAlexW3186996205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.