Evidence map›Paper›PMID 34311565›Full record

ArticleStroke2021

Rapid Assessment of Blood Pressure Variability and Outcome After Successful Thrombectomy.

Pedro Castro, Francisca Ferreira, Cindy K Nguyen, Seyedmehdi Payabvash, Can Ozan Tan, Farzaneh Sorond, Elsa Azevedo, Nils Petersen

Open access · greenAbstract read
In one paragraph

Article in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  5. Prognostic value of beat-to-beat blood pressure variability parameters in patients after mechanical thrombectomy.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Pedro Castro *Department of Neurology, Centro Hospitalar Universitário São João, Cardiovascular R&D Unit (P.C., E.A.), Faculty of Medicine of University of Porto, Portugal.
Francisca Ferreira *Department of Clinical Neurosciences and Mental Health (F.F.), Faculty of Medicine of University of Porto, Portugal.
Cindy K NguyenNeurocritical Care and Emergency Neurology (C.K.N., N.P.), Yale School of Medicine and Yale-New Haven Hospital, CT.
Seyedmehdi PayabvashDepartment of Neuroradiology (S.P.), Yale School of Medicine and Yale-New Haven Hospital, CT.
Can Ozan TanCerebrovascular Research Laboratory and Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA (C.O.T.).
Farzaneh SorondDepartment of Neurology, Feinberg School of Medicine Northwestern University, Chicago, IL (F.S.).
Elsa AzevedoDepartment of Neurology, Centro Hospitalar Universitário São João, Cardiovascular R&D Unit (P.C., E.A.), Faculty of Medicine of University of Porto, Portugal.
Nils PetersenNeurocritical Care and Emergency Neurology (C.K.N., N.P.), Yale School of Medicine and Yale-New Haven Hospital, CT.
Yale New Haven Hospital · USNorthwestern University · USHospital de São João · PTSpaulding Rehabilitation Hospital · USUniversidade do Porto · PT

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Precision blood pressure management after endovascular stroke therapy based on real-time autoregulation measurementsK23NS110980 · NINDS · YALE UNIVERSITY · PI PETERSEN, NILS H. · 2020 to 2024
$951k
NCATS NIH HHS UL1 TR001863NINDS NIH HHS K23 NS110980
6 · The paper itself

Abstract

background and purposeHigh blood pressure (BP) variability after endovascular stroke therapy is associated with poor outcome. Conventional BP variability measures require long recordings, limiting their utility as a risk assessment tool to guide clinical decision-making. Here, we performed rapid assessment of BP variability by spectral analysis and evaluated its association with early clinical improvement and long-term functional outcomes.

methodsWe conducted a prospective study of 146 patients with anterior circulation ischemic stroke who underwent successful endovascular stroke therapy. Spectral analysis of 5-minute recordings of beat-to-beat BP was used to quantify BP variability. Outcomes included initial clinical response and modified Rankin Scale at 90 days.

resultsIncreased BP variability at high frequencies was independently associated with poor functional outcome at 90 days (adjusted odds ratio [aOR], 1.85 [95% CI, 1.07-3.25],

conclusionsHigh-frequency BP oscillations after successful reperfusion may be harmful and associate with a decreased likelihood of neurological recovery and favorable functional outcomes. Rapid assessment of BP variability throughout the postreperfusion period is feasible and may allow for a more personalized BP management.

Indexed as

ThrombectomyBlood PressureBrain IschemiaHumansHypertensionOdds RatioProspective StudiesStrokeTreatment Outcomeblood pressureclinical decision-makingischemic strokereperfusionthrombectomy

Identifiers

PMID34311565
PMCPMC8384685
OpenAlexW3187001504

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.