Evidence map›Paper›PMID 34311498›Full record

ArticleExperimental physiology2022

Altered central and peripheral haemodynamics during rhythmic handgrip exercise in young adults with SARS-CoV-2.

Nina L Stute, Abigail S L Stickford, Jonathon L Stickford, Valesha M Province, Marc A Augenreich, Kanokwan Bunsawat, Jeremy K Alpenglow, D Walter Wray, Stephen M Ratchford

Open access · bronzeAbstract read
In one paragraph

Article in Experimental physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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  8. Covid-19 special issue editorial.Experimental physiology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nina L StuteDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.ORCID 0000-0001-8213-638X
Abigail S L StickfordDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.ORCID 0000-0002-1856-1274
Jonathon L StickfordDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.
Valesha M ProvinceDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.
Marc A AugenreichDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.ORCID 0000-0002-0719-8799
Kanokwan BunsawatDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-5950-6634
Jeremy K AlpenglowDepartment of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA.
D Walter WrayDepartment of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-6907-1734
Stephen M RatchfordDepartment of Health & Exercise Science, Appalachian State University, Boone, NC, USA.ORCID 0000-0002-6300-7600
Appalachian State University · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? Are central and peripheral haemodynamics during handgrip exercise different in young adults 3-4 weeks following infection with of SARS-CoV-2 compared with young healthy adults. What is the main finding and its importance? Exercising heart rate was higher while brachial artery blood flow and vascular conductance were lower in the SARS-CoV-2 compared with the control group. These findings provide evidence for peripheral impairments to exercise among adults with SARS-CoV-2, which may contribute to exercise limitations. ABSTRACT: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can have a profound impact on vascular function. While exercise intolerance may accompany a variety of symptoms associated with SARS-CoV-2 infection, the impact of SARS-CoV-2 on exercising blood flow (BF) remains unclear. Central (photoplethysmography) and peripheral (Doppler ultrasound) haemodynamics were determined at rest and during rhythmic handgrip (HG) exercise at 30% and 45% of maximal voluntary contraction (MVC) in young adults with mild symptoms 25 days after testing positive for SARS-CoV-2 (SARS-CoV-2: n = 8M/5F; age: 21 ± 2 years; height: 176 ± 11 cm; mass: 71 ± 11 kg) and were cross-sectionally compared with control subjects (Control: n = 8M/5F; age: 27 ± 6 years; height: 178 ± 8 cm; mass: 80 ± 25 kg). Systolic blood pressure, end systolic arterial pressure and rate pressure product were higher in the SARS-CoV-2 group during exercise at 45% MVC compared with controls. Brachial artery BF was lower in the SARS-CoV-2 group at both 30% MVC (Control: 384.8 ± 93.3 ml min

Indexed as

COVID-19SARS-CoV-2AdultBrachial ArteryHand StrengthHemodynamicsHumansMuscle, SkeletalRegional Blood FlowYoung AdultCOVID-19exercising blood flownitric oxiderhythmic handgripSARS-CoV-2

Identifiers

PMID34311498
PMCPMC8447425
OpenAlexW3184724126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.