Evidence map›Paper›PMID 34311404›Full record

ReviewCurrent opinion in chemical biology2021

Advances in chemical proteomic evaluation of lipid kinases-DAG kinases as a case study.

Timothy B Ware, Ku-Lung Hsu

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Timothy B WareDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904, United States.
Ku-Lung HsuDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904, United States; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, United States; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, United States; University of Virginia Cancer Center, University of Virginia, Charlottesville, VA 22903, USA. Electronic address: kenhsu@virginia.edu.
University of Virginia · USUniversity of Virginia Cancer Center

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jay William FOX · 1987 to 2026
$72.1M
Endocannabinoid Biosynthesis in Inflammation and PainR01DA043571 · NIDA · UNIVERSITY OF VIRGINIA · PI Ku-Lung Hsu · 2017 to 2026
$3.5M
Elucidating diacylglycerol lipase beta-mediated effects on neuroinflammatory signalingF31DA053107 · NIDA · UNIVERSITY OF VIRGINIA · PI WARE, TIMOTHY BRANDON · 2021 to 2021
$13k
NCI NIH HHS P30 CA044579NIDA NIH HHS F31 DA053107NIDA NIH HHS R01 DA043571
6 · The paper itself

Abstract

Advancements in chemical proteomics and mass spectrometry lipidomics are providing new opportunities to understand lipid kinase activity, specificity, and regulation on a global cellular scale. Here, we describe recent developments in chemical biology of lipid kinases with a focus on those members that phosphorylate diacylglycerols. We further discuss future implications of how these mass spectrometry-based approaches can be adapted for studies of additional lipid kinase members with the aim of bridging the gap between protein and lipid kinase-focused investigations.

Indexed as

Diacylglycerol KinaseProteomicsLipidsMass SpectrometryPhosphotransferasesDiacylglycerol KinaseLipidsPhosphotransferasesActivity-based protein profilingChemical proteomicsDiacylglycerolKinaseKinomeLipidLipidomicsMass spectrometryPhosphatidic acidPhosphoinositidePhosphorylationSignalingSuFExSulfonyl fluoridesSulfonyl triazolesSuTEx

Identifiers

PMID34311404
PMCPMC8671151
OpenAlexW3185472668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.