Evidence map›Paper›PMID 34311291›Full record

ArticleJournal of biomechanics2021

Sexual dimorphisms in three-dimensional masticatory muscle attachment morphometry regulates temporomandibular joint mechanics.

Xin She, Shuchun Sun, Brooke J Damon, Cherice N Hill, Matthew C Coombs, Feng Wei, Michael K Lecholop, Martin B Steed, Thierry H Bacro, Elizabeth H Slate and 3 more

Open access · greenAbstract read
In one paragraph

Article in Journal of biomechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Xin SheDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Shuchun SunDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Brooke J DamonDepartment of Bioengineering, Clemson University, Clemson, SC, USA; Department of Oral Health Sciences, Medical University of South Carolina (MUSC), Charleston, SC, USA.
Cherice N HillDepartment of Bioengineering, Clemson University, Clemson, SC, USA; Department of Oral Health Sciences, Medical University of South Carolina (MUSC), Charleston, SC, USA.
Matthew C CoombsDepartment of Bioengineering, Clemson University, Clemson, SC, USA; Department of Oral Health Sciences, Medical University of South Carolina (MUSC), Charleston, SC, USA.
Feng WeiDepartment of Bioengineering, Clemson University, Clemson, SC, USA.
Michael K LecholopDepartment of Oral and Maxillofacial Surgery, MUSC, Charleston, SC, USA.
Martin B SteedDepartment of Oral and Maxillofacial Surgery, MUSC, Charleston, SC, USA.
Thierry H BacroCenter for Anatomical Studies and Education, MUSC, Charleston, SC, USA.
Elizabeth H SlateDepartment of Statistics, Florida State University, Tallahassee, FL, USA.
Naiquan ZhengDepartment of Mechanical Engineering and Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC, USA.
Janice S LeeNIH NIDCR, Bethesda, MD, USA.
Hai YaoDepartment of Bioengineering, Clemson University, Clemson, SC, USA; Department of Oral Health Sciences, Medical University of South Carolina (MUSC), Charleston, SC, USA. Electronic address: haiyao@clemson.edu.
Medical University of South Carolina · USClemson University · USFlorida State University · USNational Institute of Dental and Craniofacial Research · USUniversity of North Carolina at Charlotte · US

Funding

Tissue Structural and Neural Remodeling in Human Sacroiliac JointP20GM121342 · NIGMS · CLEMSON UNIVERSITY · PI Hai Yao · 2018 to 2026
$24.7M
Craniofacial Anomalies and RegenerationZIADE000746 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI LEE, JANICE · 2015 to 2025
$12.3M
T-COHR: Training in Craniofacial and Oral Health ResearchT32DE017551 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAO, HAI · 2006 to 2025
$10.3M
Integrating craniofacial morphology, oral function, temporomandibular biomechanics and mechanobiology to determine sex-specific TMJ pathophysiology in humansR01DE021134 · NIDCR · CLEMSON UNIVERSITY · PI YAO, HAI · 2012 to 2025
$4.7M
Biophysical Modeling of Fluid and Solute Transport in the TMJ DiscR03DE018741 · NIDCR · CLEMSON UNIVERSITY · PI YAO, HAI · 2009 to 2010
$223k
Structure-function relationships between human temporomandibular lateral capsule-ligament complex tensile stiffness, collagen ultrastructure and ECM composition: Investigation of sexual dimorphismsF32DE027864 · NIDCR · CLEMSON UNIVERSITY · PI COOMBS, MATTHEW CHATTERJEE · 2018 to 2018
$40k
NIDCR NIH HHS F32 DE027864NIDCR NIH HHS R01 DE021134NIDCR NIH HHS R03 DE018741NIDCR NIH HHS T32 DE017551NIGMS NIH HHS P20 GM121342
6 · The paper itself

Abstract

Temporomandibular joint (TMJ) disorders disproportionally affect females, with female to male prevalence varying from 3:1 to 8:1. Sexual dimorphisms in masticatory muscle attachment morphometry and association with craniofacial size, critical for understanding sex-differences in TMJ function, have not been reported. The objective of this study was to determine sex-specific differences in three-dimensional (3D) TMJ muscle attachment morphometry and craniofacial sizes and their impact on TMJ mechanics. Human cadaveric TMJ muscle attachment morphometry and craniofacial anthropometry (10Males; 11Females) were determined by previously developed 3D digitization and imaging-based methods. Sex-differences in muscle attachment morphometry and craniofacial anthropometry, and their correlation were determined, respectively using multivariate general linear and linear regression statistical models. Subject-specific musculoskeletal models of the mandible were developed to determine effects of sexual dimorphisms in mandibular size and TMJ muscle attachment morphometry on joint loading during static biting. There were significant sex-differences in craniofacial size (p = 0.024) and TMJ muscle attachment morphometry (p < 0.001). TMJ muscle attachment morphometry was significantly correlated with craniofacial size. TMJ contact forces estimated from biomechanical models were significantly, 23% on average (p < 0.001), greater for females compared to those for males when generating the same bite forces. There were significant linear correlations between TMJ contact force and both 3D mandibular length (R

Indexed as

Sex CharacteristicsTemporomandibular JointBite ForceFemaleHumansMaleMandibleMasticatory MusclesCraniofacial morphologyMuscle attachmentMusculoskeletal modellingSexual dimorphismTemporomandibular joint

Identifiers

PMID34311291
PMCPMC8453136
OpenAlexW3179521072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.