ArticleEpilepsy & behavior : E&B2021
Dynamic FDG-PET in localization of focal epilepsy: A pilot study.
Article in Epilepsy & behavior : E&B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nuclear imaging for localization and surgical outcome prediction in epilepsy: A review of latest discoveries and future perspectives.Frontiers in neurology · 2022Pooled it
- An end-to-end deep learning pipeline to derive blood input with partial volume corrections for automated parametric brain PET mapping.Biomedical physics & engineering express · 2024Article
- Real-time motion-enabling positron emission tomography of the brain of upright ambulatory humans.Communications medicine · 2024Article
- A Review of EEG-based Localization of Epileptic Seizure Foci: Common Points with Multimodal Fusion of Brain Data.Journal of medical signals and sensors · 2024Review
- Accurate brain pharmacokinetic parametric imaging using the blood input function extracted from the cavernous sinus.American journal of nuclear medicine and molecular imaging · 2024Article
- Microglial activation persists beyond clinical recovery following sport concussion in collegiate athletes.Frontiers in neurology · 2023Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Dynamic FDG-PET demonstration of functional brain abnormalities.Annals of clinical and translational neurology · 2022Review
- Advanced neuroimaging techniques in epilepsy.Current opinion in neurology · 2022Review
- Clinical and Instrumental Characterization of Patients With Late-Onset Epilepsy.Frontiers in neurology · 2022Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Epilepsy surgery remains underutilized, in part because non-invasive methods of potential seizure foci localization are inadequate. We used high-resolution, parametric quantification from dynamic 2-[18F] fluoro-2-deoxy-d-glucose positron emission tomography (dFDG-PET) imaging to locate hypometabolic foci in patients whose standard clinical static PET images were normal. We obtained dFDG-PET brain images with simultaneous EEG in a one-hour acquisition on seven patients with no MRI evidence of focal epilepsy to record uptake and focal radiation decay. Images were attenuation- and motion-corrected and co-registered with high-resolution T1-weighted patient MRI and segmented into 18 regions of interest (ROI) per hemisphere. Tracer uptake was calibrated with a model corrected blood input function with partial volume (PV) corrections to generate tracer parametric maps compared between mean radiation values between hemispheres with z-scores. We identified ROI with the lowest negative z scores (<-1.65 SD) as hypometabolic. Dynamic 2-[18F] fluoro-2-deoxy-d-glucose positron emission tomography ( found focal regions of altered metabolism in all cases in which standard clinical FDG-PET found no abnormalities. This pilot study of dynamic FDG-PET suggests that further research is merited to evaluate whether glucose dynamics offer improved clinical utility for localization of epileptic foci over standard static techniques.
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