Evidence map›Paper›PMID 34311114›Full record

ArticleEnvironmental toxicology and pharmacology2021

Developmental phenotypic and transcriptomic effects of exposure to nanomolar levels of metformin in zebrafish.

Jessica Phillips, Camille Akemann, Jeremiah N Shields, Chia-Chen Wu, Danielle N Meyer, Bridget B Baker, David K Pitts, Tracie R Baker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental toxicology and pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Developmental effects ofTrends in developmental biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jessica PhillipsInstitute of Environmental Health Sciences, Wayne State University, 6135 Woodward Ave, Detroit, MI, 48202, USA; Department of Pharmacology, Wayne State University, 540 E Canfield, Detroit, MI, 28201, USA.
Camille AkemannInstitute of Environmental Health Sciences, Wayne State University, 6135 Woodward Ave, Detroit, MI, 48202, USA; Department of Pharmacology, Wayne State University, 540 E Canfield, Detroit, MI, 28201, USA.
Jeremiah N ShieldsInstitute of Environmental Health Sciences, Wayne State University, 6135 Woodward Ave, Detroit, MI, 48202, USA.
Chia-Chen WuInstitute of Environmental Health Sciences, Wayne State University, 6135 Woodward Ave, Detroit, MI, 48202, USA.
Danielle N MeyerInstitute of Environmental Health Sciences, Wayne State University, 6135 Woodward Ave, Detroit, MI, 48202, USA; Department of Pharmacology, Wayne State University, 540 E Canfield, Detroit, MI, 28201, USA.
Bridget B BakerInstitute of Environmental Health Sciences, Wayne State University, 6135 Woodward Ave, Detroit, MI, 48202, USA.
David K PittsDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.
Tracie R BakerInstitute of Environmental Health Sciences, Wayne State University, 6135 Woodward Ave, Detroit, MI, 48202, USA; Department of Pharmacology, Wayne State University, 540 E Canfield, Detroit, MI, 28201, USA. Electronic address: tracie.baker@wayne.edu.
Wayne State University · US

Funding

Pilot Project ProgramP30ES020957 · NIEHS · WAYNE STATE UNIVERSITY · PI RUNGE-MORRIS, MELISSA A · 2014 to 2021
$10.1M
Genetic and epigenetic mechanisms of infertility caused by endocrine disrupting chemicalsR01ES030722 · NIEHS · WAYNE STATE UNIVERSITY · PI BAKER, TRACIE R · 2020 to 2025
$2.1M
Adult and Transgenerational Toxicity Due to Developmental TCDD ExposureK01OD010462 · OD · WAYNE STATE UNIVERSITY · PI BAKER, TRACIE R · 2013 to 2017
$657k
Investigating the Developmental Mechanisms of TCDD-Induced Reproductive DysregulationF31ES030278 · NIEHS · WAYNE STATE UNIVERSITY · PI MEYER, DANIELLE · 2019 to 2021
$129k
NIEHS NIH HHS F31 ES030278NIEHS NIH HHS P30 ES020957NIEHS NIH HHS R01 ES030722NIH HHS K01 OD010462
6 · The paper itself

Abstract

Metformin is found in the majority of lakes and streams in the United States, leading to widespread environmental exposure. Results of the present study indicate that extended duration metformin exposure at critical developmental periods leads to decreased survival rates in zebrafish (danio rerio), an NIH approved human model. Significant abnormalities are seen with extended duration metformin exposure from 4 h post fertilization up to 5 days post fertilization, although short term metformin exposure for 24 h at 4-5 days post fertilization did not lead to any significant abnormalities. Both extended and short term duration did however have an impact on locomotor activity of zebrafish, and several genes involved in neurological and cardiovascular development were differentially expressed after exposure to metformin. The changes seen in behavior, gene expression and morphological abnormalities caused by metformin exposure should be examined further in future studies in order to assess their potential human health implications as metformin prescriptions continue to increase worldwide.

Indexed as

ZebrafishAnimalsBehavior, AnimalBone and BonesEdema, CardiacEmbryonic DevelopmentEmbryo, NonmammalianFemaleLocomotionMaleMetforminPhenotypeTeratogensTranscriptomeWater Pollutants, ChemicalMetforminTeratogensWater Pollutants, ChemicalAquatic environmentDanio rerioEnvironmental toxicityGround water chemicalsMetforminZebrafish

Identifiers

PMID34311114
PMCPMC8446320
OpenAlexW3186256611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.