Evidence map›Paper›PMID 34311080›Full record

ReviewBiochimica et biophysica acta. Molecular basis of disease2021

Pregnancy and pandemics: Interaction of viral surface proteins and placenta cells.

Paulina Fuentes-Zacarías, Jose M Murrieta-Coxca, Ruby N Gutiérrez-Samudio, Astrid Schmidt, Andre Schmidt, Udo R Markert, Diana M Morales-Prieto

Open access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Molecular basis of disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Monkeypox Virus and Pregnancy.Journal of medical virology · 2025
    Review
  4. Neurogenesis decreases in the offspring of mothers infected with influenza A virus.Frontiers in cellular and infection microbiology · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Paulina Fuentes-ZacaríasPlacenta Lab, Department of Obstetrics, Jena University Hospital, 07747 Jena, Germany.
Jose M Murrieta-CoxcaPlacenta Lab, Department of Obstetrics, Jena University Hospital, 07747 Jena, Germany.
Ruby N Gutiérrez-SamudioPlacenta Lab, Department of Obstetrics, Jena University Hospital, 07747 Jena, Germany.
Astrid SchmidtPlacenta Lab, Department of Obstetrics, Jena University Hospital, 07747 Jena, Germany.
Andre SchmidtPlacenta Lab, Department of Obstetrics, Jena University Hospital, 07747 Jena, Germany.
Udo R MarkertPlacenta Lab, Department of Obstetrics, Jena University Hospital, 07747 Jena, Germany.. Electronic address: markert@med.uni-jena.de.
Diana M Morales-PrietoPlacenta Lab, Department of Obstetrics, Jena University Hospital, 07747 Jena, Germany.. Electronic address: Diana.Morales@med.uni-jena.de.
Jena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Throughout history, pandemics of infectious diseases caused by emerging viruses have spread worldwide. Evidence from previous outbreaks demonstrated that pregnant women are at high risk of contracting the diseases and suffering from adverse outcomes. However, while some viruses can cause major health complications for the mother and her fetus, others do not appear to affect pregnancy. Viral surface proteins bind to specific receptors on the cellular membrane of host cells and begin therewith the infection process. During pregnancy, the molecular features of these proteins may determine specific target cells in the placenta, which may explain the different outcomes. In this review, we display information on Variola, Influenza, Zika and Corona viruses focused on their surface proteins, effects on pregnancy, and possible target placental cells. This will contribute to understanding viral entry during pregnancy, as well as to develop strategies to decrease the incidence of obstetrical problems in current and future infections.

Indexed as

FemaleHumansPlacentaPregnancyPregnancy Complications, InfectiousSARS-CoV-2Variola virusViral Envelope ProteinsVirus DiseasesZika VirusViral Envelope ProteinsCoronavirusInfluenzaPregnancyVariolaZika

Identifiers

PMID34311080
PMCPMC9188292
OpenAlexW3184981489

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.