ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2021
Atopic dermatitis trajectories to age 8 years in the GUSTO cohort.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Unraveling the Natural History of Atopic Dermatitis: Prospective Disease Trajectories and Longitudinal IgE Sensitization from Birth to Adolescence.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Current research landscape and future prospects of in silico modeling approaches for atopic dermatitis.JID innovations : skin science from molecules to population health · 2026Review
- Phenotypes of atopic dermatitis and long-term body mass index trajectories.Pediatric research · 2026Article
- Atopic dermatitis/eczema phenotypes and their association with food allergy: a nationwide birth cohort study in Japan.European journal of pediatrics · 2026Article
- Untangling the Complexity of Childhood Atopic Dermatitis: Phenotypes and Endotypes.Clinical reviews in allergy & immunology · 2026Review
- Artificial Intelligence-Assisted Diagnosis of Atopic Eczema in Darker Skin Types: A CNN-Based Study.Dermatology practical & conceptual · 2026Article
- Developments in the Management Strategies for Allergy: Advances in Artificial Intelligence and Future Perspectives.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2026Review
- The Impact of Early-Life, Long-Term Exposure to Ambient Particulate Matter on Atopic Dermatitis Remission and Sensitization in Infants.Journal of Korean medical science · 2025Article
- Atopic dermatitis and executive function across early and middle childhood - A longitudinal cohort study of children in the United Kingdom.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- 2023 Consensus Korean Diagnostic Criteria for Atopic Dermatitis.Annals of dermatology · 2025Article
- Machine learning-derived phenotypic trajectories of asthma and allergy in children and adolescents: protocol for a systematic review.BMJ open · 2024Article
- Prevalence of allergic rhinitis, atopic dermatitis, and wheezing at 15 and 22 years of age: the 1993 Pelotas (Brazil) Birth Cohort Study.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024Article
- Identification of eczema clusters and their association with filaggrin and atopic comorbidities: analysis of five birth cohorts.The British journal of dermatology · 2023Article
- Eczema among adolescents in Kuwait: Prevalence, severity, sleep disturbance, antihistamine use, and risk factors.The World Allergy Organization journal · 2023Article
- Atopic Dermatitis With Coexisting Food Allergy in Early Life Is Associated With Childhood Asthma.Allergy, asthma & immunology research · 2022Article
- Establishing subclasses of childhood eczema, their risk factors and prognosis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Review
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe heterogeneity of childhood atopic dermatitis (AD) underscores the need to understand latent phenotypes that may inform risk stratification and disease prognostication.
objectiveTo identify AD trajectories across the first 8 years of life and investigate risk factors associated with each trajectory and their relationships with other comorbidities.
methodsData were collected prospectively from 1152 mother-offspring dyads in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort from ages 3 months to 8 years. AD was defined based on parent-reported doctor's diagnosis. An unsupervised machine learning technique was used to determine AD trajectories.
resultsThree AD trajectories were identified as follows: early-onset transient (6.3%), late-onset persistent (6.3%) and early-onset persistent (2.1%), alongside a no AD/reference group (85.2%). Early-onset transient AD was positively associated with male gender, family history of atopy, house dust mite sensitization and some measures of wheezing. Early-onset persistent AD was associated with antenatal/intrapartum antibiotic use, food sensitization and some measures of wheezing. Late-onset persistent AD was associated with a family history of atopy, some measures of house dust mite sensitization and some measures of allergic rhinitis and wheezing. CONCLUSION AND CLINICAL RELEVANCE: Three AD trajectories were identified in this birth cohort, with different risk factors and prognostic implications. Further work is needed to understand the molecular and immunological origins of these phenotypes.
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