Evidence map›Paper›PMID 34310652›Full record

ArticlePloS one2021

Urinary actin, as a potential marker of sepsis-related acute kidney injury: A pilot study.

Dániel Ragán, Péter Kustán, Zoltán Horváth-Szalai, Balázs Szirmay, Beáta Bugyi, Andrea Ludány, Attila Miseta, Bálint Nagy, Diána Mühl

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04968262 (Urinary Actin, as a Potential Marker of Sepsis-related Acute Kidney Injury), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04968262 completednot on this map

Urinary Actin, as a Potential Marker of Sepsis-related Acute Kidney Injury: a Pilot Study

TypeobservationalSponsorUniversity of PecsRan2016 to 2019Enrolled84ConditionsSepsis, Acute Kidney Injury Due to SepsisArmsSepsis therapy, Sepsis-related acute kidney injury therapy
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dániel RagánDepartment of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary.ORCID 0000-0002-5429-0168
Péter KustánDepartment of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary.
Zoltán Horváth-SzalaiDepartment of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary.
Balázs SzirmayDepartment of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary.
Beáta BugyiDepartment of Biophysics, Medical School, University of Pécs, Pécs, Hungary.
Andrea LudányDepartment of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary.
Attila MisetaDepartment of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary.
Bálint NagyDepartment of Anesthesiology and Intensive Therapy, Medical School, University of Pécs, Pécs, Hungary.ORCID 0000-0002-4865-8958
Diána MühlDepartment of Anesthesiology and Intensive Therapy, Medical School, University of Pécs, Pécs, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA major complication of sepsis is the development of acute kidney injury (AKI). Recently, it was shown that intracellular actin released from damaged tissues appears in the urine of patients with multiple organ dysfunction syndrome. Our aims were to measure urinary actin (u-actin) concentrations of septic and control patients and to test if u-actin levels could predict AKI and mortality.

methodsBlood and urine samples were collected from septic and sepsis-related AKI patients at three time points (T1-3): T1: within 24 hours after admission; T2: second day morning; T3: third day morning of follow-up. Patients with malignancies needing palliative care, end-stage renal disease or kidney transplantation were excluded. Serum and u-actin levels were determined by quantitative Western blot. Patients were categorized by the Sepsis-3 and KDIGO AKI classifications.

resultsIn our study, 17 septic, 43 sepsis-induced AKI and 24 control patients were enrolled. U-actin levels were higher in septic patients compared with controls during follow-up (p<0.001). At T1, the septic and sepsis-related AKI groups also showed differences (p<0.001), yet this increase was not statistically significant at T2 and T3. We also detected significantly elevated u-actin concentrations in AKI-2 and AKI-3 septic patients compared with AKI-1 septic patients (p<0.05) at T1 and T3, along with a significant increase in AKI-2 septic patients compared with AKI-1 septic patients at T2 (p<0.01). This tendency remained the same when referring u-actin to urine creatinine. Parameters of first-day septic patient samples could discriminate AKI from non-AKI state (AUC ROC, p<0.001): u-actin: 0.876; se-creatinine: 0.875. Derived cut-off value for u-actin was 2.63 μg/L (sensitivity: 86.0%, specificity: 82.4%).

conclusionU-actin may be a complementary diagnostic biomarker to se-creatinine in sepsis-related AKI while higher u-actin levels also seem to reflect the severity of AKI. Further investigations may elucidate the importance of u-actin release in sepsis-related AKI.

Indexed as

ActinsAcute Kidney InjuryAgedArea Under CurveBiomarkersCase-Control StudiesCreatinineFemaleHumansMaleMiddle AgedPilot ProjectsROC CurveSepsisSeverity of Illness IndexSurvival AnalysisActinsBiomarkersCreatinine

Identifiers

PMID34310652
PMCPMC8312921
OpenAlexW3184723361

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.