ArticlePloS one2021
Aggravation of Reflux Finding Score (RFS) after thyroidectomy.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Post-thyroidectomy anterior neck dysfunction: clinical phenotypes, mechanisms, and comprehensive management.Frontiers in endocrinology · 2026Review
- Comparison of Voice and Swallowing Changes After Thyroidectomy Using the Gasless Transaxillary, Transoral, and Conventional Transcervical Approaches: A Network Meta-analysis.Annals of surgical oncology · 2025Review
- Postoperative laryngeal granuloma in mediastinal goitre with gastro-oesophageal reflux disease.BMJ case reports · 2024Article
- Post-thyroidectomy voice and swallowing disorders and association with laryngopharyngeal reflux: A scoping review.Laryngoscope investigative otolaryngology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laryngopharyngeal reflux (LPR) has been suggested as a possible cause of post-thyroidectomy syndrome. However, the pathophysiology and relationship between thyroidectomy and LPR have not been well investigated. We aimed to evaluate the correlation between thyroidectomy and LPR by assessing changes in LPR-related symptoms and laryngoscopic findings before and after thyroidectomy. Ninety-five patients who underwent thyroidectomy with or without central neck dissection were included. The reflux finding score (RFS) and reflux symptom index (RSI) were investigated one day before surgery and two, four, six, and twelve months after surgery. The RFS scores increased significantly after thyroidectomy and decreased to the preoperative level 12 months after surgery. The RSI scores increased after surgery and decreased gradually by 12 months postoperatively, although it was not statistically significant. The RSI and RFS scores improved with the administration of proton pump inhibitors. In conclusion, LPR-related laryngoscopic findings were exacerbated after uncomplicated thyroidectomy. Further studies using pH-monitoring and esophageal manometry are required to investigate the possible deterioration of LPR itself and the UES pressure after thyroidectomy.
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