Evidence map›Paper›PMID 34310599›Full record

ArticlePloS one2021

UV decontamination of personal protective equipment with idle laboratory biosafety cabinets during the COVID-19 pandemic.

Davis T Weaver, Benjamin D McElvany, Vishhvaan Gopalakrishnan, Kyle J Card, Dena Crozier, Andrew Dhawan, Mina N Dinh, Emily Dolson, Nathan Farrokhian, Masahiro Hitomi and 17 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. The COVID-19 pandemic and N95 masks: reusability and decontamination methods.Antimicrobial resistance and infection control · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 8 institutions in 2 countries.

Davis T WeaverCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0003-3086-497X
Benjamin D McElvanyUniversity of Vermont Medical Center, Burlington, VT, United States of America.ORCID 0000-0002-0226-7222
Vishhvaan GopalakrishnanCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0002-0532-7710
Kyle J CardCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0002-0462-2777
Dena CrozierCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0002-1841-0011
Andrew DhawanCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0002-5027-1277
Mina N DinhCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Emily DolsonCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0001-8616-4898
Nathan FarrokhianCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0001-8731-4464
Masahiro HitomiCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0002-0937-6640
Emily HoCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Tanush JagdishDana Farber Cancer Insitute, Harvard University, Boston, MA, United States of America.ORCID 0000-0003-0252-6201
Eshan S KingCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0002-0345-3780
Jennifer L CadnumLouis Stokes Cleveland VA, Cleveland, United States of America.
Curtis J DonskeyLouis Stokes Cleveland VA, Cleveland, United States of America.
Nikhil KrishnanCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0002-3755-6120
Gleb KuzminCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Ju LiMassachusetts Institute of Technology, Cambridge, MA, United States of America.
Jeff MaltasUniversity of Michigan, Ann Arbor, MI, United States of America.ORCID 0000-0001-6567-6800
Jinhan MoTsinghua University, Beijing, China.ORCID 0000-0002-3178-6507
Julia PeleskoCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Jessica A ScarboroughCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0002-5365-5735
Geoff SedorCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.
Enze TianMassachusetts Institute of Technology, Cambridge, MA, United States of America.ORCID 0000-0001-6410-5360
Gary C AnUniversity of Vermont Medical Center, Burlington, VT, United States of America.ORCID 0000-0003-4549-9004
Sean A DiehlUniversity of Vermont Medical Center, Burlington, VT, United States of America.ORCID 0000-0001-9700-235X
Jacob G ScottCleveland Clinic Lerner Research Institute and Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.ORCID 0000-0003-2971-7673
Cleveland Clinic Lerner College of Medicine · USUniversity of Vermont Medical Center · USLouis Stokes Cleveland VA Medical Center · USMassachusetts Institute of Technology · USCleveland Clinic · USHarvard University · USTsinghua University · CNUniversity of Michigan · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Personal protective equipment (PPE) is crucially important to the safety of both patients and medical personnel, particularly in the event of an infectious pandemic. As the incidence of Coronavirus Disease 2019 (COVID-19) increases exponentially in the United States and many parts of the world, healthcare provider demand for these necessities is currently outpacing supply. In the midst of the current pandemic, there has been a concerted effort to identify viable ways to conserve PPE, including decontamination after use. In this study, we outline a procedure by which PPE may be decontaminated using ultraviolet (UV) radiation in biosafety cabinets (BSCs), a common element of many academic, public health, and hospital laboratories. According to the literature, effective decontamination of N95 respirator masks or surgical masks requires UV-C doses of greater than 1 Jcm-2, which was achieved after 4.3 hours per side when placing the N95 at the bottom of the BSCs tested in this study. We then demonstrated complete inactivation of the human coronavirus NL63 on N95 mask material after 15 minutes of UV-C exposure at 61 cm (232 μWcm-2). Our results provide support to healthcare organizations looking for methods to extend their reserves of PPE.

Indexed as

PandemicsUltraviolet RaysContainment of BiohazardsCOVID-19DecontaminationDose-Response Relationship, RadiationEquipment ReuseHealth PersonnelHumansLaboratoriesMasksN95 RespiratorsRadiometrySARS-CoV-2

Identifiers

PMID34310599
PMCPMC8312969
OpenAlexW3184752776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.