Evidence map›Paper›PMID 34310595›Full record

ArticlePloS one2021

Urinary soluble (pro)renin receptor excretion is associated with urine pH in humans.

Nobukazu Sasaki, Satoshi Morimoto, Chikahito Suda, Satoru Shimizu, Atsuhiro Ichihara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nobukazu SasakiDepartment of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.
Satoshi MorimotoDepartment of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.ORCID 0000-0002-2292-2319
Chikahito SudaDepartment of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.
Satoru ShimizuSchool of Arts and Sciences, Tokyo Woman's Christian University, Tokyo, Japan.
Atsuhiro IchiharaDepartment of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.
Tokyo Women's Medical University · JPTokyo Woman's Christian University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The (pro)renin receptor [(P)RR] binds to renin and its precursor prorenin to activate the tissue renin-angiotensin system. It is cleaved to generate soluble (P)RR and M8-9, a residual hydrophobic truncated protein. The (pro)renin receptor also functions as an intracellular accessory protein of vacuolar-type H+-ATPase, which plays an essential role in controlling the intracellular vesicular acid environment. Thus, in the kidney, (P)RR may play a role in transporting H+ to urine in the collecting duct. Although blood soluble (P)RR has been recognized as a biomarker reflecting the status of the tissue renin-angiotensin system and/or tissue (P)RR, the significance of urinary soluble (P)RR excretion has not been determined. Therefore, this study aimed to investigate the characteristics of urinary soluble (P)RR excretion. Urinary soluble (P)RR excretion was measured, and its association with background factors was investigated in 441 patients. Relationships between changes in urine pH due to vitamin C treatment, which reduce urine pH, and urinary soluble (P)RR excretion were investigated in 10 healthy volunteers. Urinary soluble (P)RR excretion was 1.46 (0.44-2.92) ng/gCre. Urine pH showed a significantly positive association with urinary soluble (P)RR excretion, independent of other factors. Changes in urine pH and urinary soluble (P)RR excretion due to vitamin C treatment were significantly and positively correlated (ρ = 0.8182, p = 0.0038). These data showed an association between urinary soluble (P)RR excretion and urine pH in humans, suggesting that (P)RR in the kidney might play a role in urine pH regulation.

Indexed as

AdultBiological TransportHumansHydrogen-Ion ConcentrationHypertensionKidneyKidney Tubules, CollectingMiddle AgedProrenin ReceptorReceptors, Cell SurfaceReninRenin-Angiotensin SystemVacuolar Proton-Translocating ATPasesATP6AP2 protein, humanProrenin ReceptorReceptors, Cell SurfaceReninVacuolar Proton-Translocating ATPases

Identifiers

PMID34310595
PMCPMC8312976
OpenAlexW3186118705

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.