Evidence map›Paper›PMID 34310246›Full record

ReviewThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2021

Histological Studies of the Ventricular-Subventricular Zone as Neural Stem Cell and Glioma Stem Cell Niche.

Asa A Brockman, Bret C Mobley, Rebecca A Ihrie

Abstract readReview
In one paragraph

Review in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024
    Review
  4. Glioblastoma Therapy: Past, Present and Future.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Article
  7. Glioblastoma and Methionine Addiction.International journal of molecular sciences · 2022
    Review
  8. Cell Biology Meets Cell Metabolism: Energy Production Is Similar in Stem Cells and in Cancer Stem Cells in Brain and Bone Marrow.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Asa A BrockmanDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Bret C MobleyDepartments of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.
Rebecca A IhrieDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.

Funding

Identifying mTOR Dependent Periods During Brain DevelopmentR01NS118580 · NINDS · VANDERBILT UNIVERSITY · PI ESS, KEVIN C, IHRIE, REBECCA A · 2020 to 2024
$2.1M
Quantifying Differences in mTOR Activity and Tumor Development Between Neural Stem Cell MicrodomainsR01NS096238 · NINDS · VANDERBILT UNIVERSITY · PI IHRIE, REBECCA A · 2016 to 2020
$1.7M
NINDS NIH HHS R01 NS096238NINDS NIH HHS R01 NS118580
6 · The paper itself

Abstract

The neural stem cell niche of the ventricular-subventricular zone supports the persistence of stem and progenitor cells in the mature brain. This niche has many notable cytoarchitectural features that affect the activity of stem cells and may also support the survival and growth of invading tumor cells. Histochemical studies of the niche have revealed many proteins that, in combination, can help to reveal stem-like cells in the normal or cancer context, although many caveats persist in the quest to consistently identify these cells in the human brain. Here, we explore the complex relationship between the persistent proliferative capacity of the neural stem cell niche and the malignant proliferation of brain tumors, with a special focus on histochemical identification of stem cells and stem-like tumor cells and an eye toward the potential application of high-dimensional imaging approaches to the field.

Indexed as

AnimalsBrainBrain NeoplasmsCell DifferentiationCell ProliferationDoublecortin Domain ProteinsGliomaHumansLateral VentriclesNeoplastic Stem CellsNestinNeural Stem CellsStem Cell NicheDoublecortin Domain ProteinsNestinangiogenesisglioblastomaglioma stem cellimage analysismass cytometrymultiplex imagingneural stem cellSEZstemnessSVZtumor heterogeneitytumor immune infiltratetumor microenvironmentV-SVZ

Identifiers

PMID34310246
PMCPMC8647632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.