Evidence map›Paper›PMID 34310061›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease: Results from the MOPEAD project.

Mercè Boada, Adrián Rodrigo, Frank Jessen, Bengt Wimblad, Milica G Kramberger, Pieter Jelle Visser, Rafael Simó, Octavio Rodríguez-Gomez, Andreea Ciudin, Jean Georges and 19 more

Open access · hybridAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Alzheimer's disease diagnosis and management: Perspectives from around the world.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 20 institutions in 11 countries.

Mercè BoadaResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya, Barcelona, Spain.ORCID 0000-0003-2617-3009
Adrián RodrigoGMV SECURE E SOLUTIONS, Valencia, Spain.
Frank JessenDepartment of Psychiatry, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Bengt WimbladDivision of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Milica G KrambergerDepartment of Neurology, University Medical Center Ljubljana and Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Pieter Jelle VisserAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Rafael SimóInstitut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain.
Octavio Rodríguez-GomezResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya, Barcelona, Spain.
Andreea CiudinInstitut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain.
Jean GeorgesAlzheimer Europe, Luxembourg.
Annete DumasASDM Consulting, Brussels, Belgium.
Peggy MaguireEuropean Institute of Women's Health, Dublin, Ireland.
David KrivecZdruzenje Spomincica, Ljubljana, Slovenia.
Anders WimoDivision of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Sergi ValeroResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya, Barcelona, Spain.
Montserrat AlegretResearch Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades - Universitat Internacional de Catalunya, Barcelona, Spain.
Laura JamilisGMV SECURE E SOLUTIONS, Valencia, Spain.
Marissa ZwanAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Lena SannemannDepartment of Psychiatry, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Jordi ArrufatEAP Sarrià-Vallvidrera-Les Planes, Barcelona, Spain.
Erik StomrudClinical Memory Research Unit, Lund University, Malmö, Sweden.
Gunilla JohanssonDivision of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Craig SheringAstraZeneca, Waltham, Massachusetts, USA.
Bridget GlaysherModus Research and Innovation Limited, Dundee, Scotland.
Neil StewartModus Research and Innovation Limited, Dundee, Scotland.
Mark BelgerEli Lilly and Company (Lilly UK), Surrey, UK.
Fatima IradierEli Lilly and Company, Spain.
Laura CampoEli Lilly and Company, Firenze, Italy.
MOPEAD consortium
Instituto de Salud Carlos III · ESDundee and Angus College · GBGMV Innovating Solutions (Spain) · ESKarolinska Institutet · SEUniversitat Autònoma de Barcelona · ESUniversity of Cologne · DEAlzheimer Europe · LUAmsterdam Neuroscience · NLAstraZeneca (United Kingdom) · GBEli Lilly (Italy) · ITEli Lilly (Spain) · ESEli Lilly (United Kingdom) · GBEuropean Institute of Women's Health · IEFundació ACE · ESHealth Insurance Institute of Slovenia · SIKarolinska University Hospital · SELund University · SEMaastricht University · NLMinerva Consulting and Communication · BEUniversity of Ljubljana · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis.

methodsFour different strategies or RUNs were used: (a) a web-based (WB) prescreening tool, (2) an open house initiative (OHI), (3) a primary care-based protocol for early detection of cognitive decline (PC), and (4) a tertiary care-based pre-screening at diabetologist clinics (DC).

resultsA total of 1129 patients at high risk of having prodromal AD or dementia were identified of 2847 pre-screened individuals (39.7%). The corresponding proportion for the different initiatives were 36.8% (WB), 35.6% (OHI), 44.4% (PC), and 58.3% (DC).

conclusionThese four complementary pre-screening strategies were useful for identifying individuals at high risk of having prodromal or mild AD.

Indexed as

Alzheimer DiseaseCognitive DysfunctionDementiaHumansMass ScreeningPatient ParticipationProdromal SymptomsAlzheimer's diseasediagnostic gapearly diagnosispatient engagementpopulation-based screening

Identifiers

PMID34310061
PMCPMC9290633
OpenAlexW3183248026

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.