Evidence map›Paper›PMID 34310057›Full record

ArticleOrthodontics & craniofacial research2021

Exploring palatal and dental shape variation with 3D shape analysis and geometric deep learning.

Nele Nauwelaers, Harold Matthews, Yi Fan, Balder Croquet, Hanne Hoskens, Soha Mahdi, Ahmed El Sergani, Shunwang Gong, Tianmin Xu, Michael Bronstein and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Orthodontics & craniofacial research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  7. Personalized statistical modeling of soft tissue structures in the knee.Frontiers in bioengineering and biotechnology · 2023
    Article
  8. Wear patterns in knee OA correlate with native limb geometry.Frontiers in bioengineering and biotechnology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 6 countries.

Nele NauwelaersMedical Imaging Research Center, UZ Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-9763-6106
Harold MatthewsMedical Imaging Research Center, UZ Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-0524-0025
Yi FanFacial Sciences Research Group, Murdoch Children's Research Institute, Parkville, MO, Australia.
Balder CroquetMedical Imaging Research Center, UZ Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-9539-5193
Hanne HoskensMedical Imaging Research Center, UZ Leuven, Leuven, Belgium.
Soha MahdiMedical Imaging Research Center, UZ Leuven, Leuven, Belgium.
Ahmed El SerganiCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-7680-932X
Shunwang GongDepartment of Computing, Imperial College London, London, UK.
Tianmin XuDepartment of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China.
Michael BronsteinDepartment of Computing, Imperial College London, London, UK.
Mary MarazitaCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
Seth WeinbergCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-9467-4556
Peter ClaesMedical Imaging Research Center, UZ Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0001-9489-9819
Universitair Ziekenhuis Leuven · BEUniversity of Pittsburgh · USPeking University · CNImperial College London · GBTwitter (United States) · US

Funding

Extending the Phenotype of Nonsyndromic Orofacial CleftsR01DE016148 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARAZITA, MARY L., WEINBERG, SETH M · 2004 to 2018
$19.7M
The Genetic Architecture of Human Facial MorphologyR01DE027023 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLAES, PETER, SHAFFER, JOHN R · 2017 to 2024
$5.2M
FWO PhD fellowship ISB0121NNational Institute of Dental & Craniofacial Research R01-DE016148National Institute of Dental & Craniofacial Research R01-DE027023NIDCR NIH HHS R01 DE016148NIDCR NIH HHS R01 DE027023Research Fund, KU Leuven BOF-C1Research Fund, KU Leuven C14/15/081Research Fund, KU Leuven C14/20/081Research Program of the Research Foundation Flanders G078518N
6 · The paper itself

Abstract

objectivesPalatal shape contains a lot of information that is of clinical interest. Moreover, palatal shape analysis can be used to guide or evaluate orthodontic treatments. A statistical shape model (SSM) is a tool that, by means of dimensionality reduction, aims at compactly modeling the variance of complex shapes for efficient analysis. In this report, we evaluate several competing approaches to constructing SSMs for the human palate. SETTING AND SAMPLE POPULATION: This study used a sample comprising digitized 3D maxillary dental casts from 1,324 individuals. MATERIALS AND

methodsPrincipal component analysis (PCA) and autoencoders (AE) are popular approaches to construct SSMs. PCA is a dimension reduction technique that provides a compact description of shapes by uncorrelated variables. AEs are situated in the field of deep learning and provide a non-linear framework for dimension reduction. This work introduces the singular autoencoder (SAE), a hybrid approach that combines the most important properties of PCA and AEs. We assess the performance of the SAE using standard evaluation tools for SSMs, including accuracy, generalization, and specificity.

resultsWe found that the SAE obtains equivalent results to PCA and AEs for all evaluation metrics. SAE scores were found to be uncorrelated and provided an optimally compact representation of the shapes.

conclusionWe conclude that the SAE is a promising tool for 3D palatal shape analysis, which effectively combines the power of PCA with the flexibility of deep learning. This opens future AI driven applications of shape analysis in orthodontics and other related clinical disciplines.

Indexed as

Deep LearningOrthodonticsHumansMaxillaModels, StatisticalPalatebiological shape analysisgeometric deep learningpalate

Identifiers

PMID34310057
PMCPMC8830919
OpenAlexW3186963896

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.