Evidence map›Paper›PMID 34310036›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

Genetic risk, adherence to a healthy lifestyle, and cognitive decline in African Americans and European Americans.

Klodian Dhana, Lisa L Barnes, Xiaoran Liu, Puja Agarwal, Pankaja Desai, Kristin R Krueger, Thomas M Holland, Shannon Halloway, Neelum T Aggarwal, Denis A Evans and 1 more

Open access · greenAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Effect modifiers of the MIND diet for cognition in older adults: The MIND diet trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
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  11. Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit all.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  12. Article
  13. Dementia Risk Scores,medRxiv : the preprint server for health sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Klodian DhanaRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Xiaoran LiuRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Puja AgarwalDepartment of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.
Pankaja DesaiRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Kristin R KruegerRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Thomas M HollandRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Shannon HallowayDepartment of Community, Systems and Mental Health Nursing, Rush University College of Nursing, Chicago, Illinois, USA.
Neelum T AggarwalRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Denis A EvansRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Kumar B RajanRush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Rush University Medical Center · USRush University · US

Funding

Risk Factors for Incident Alzheimer's Disease in a Biracial CommunityR01AG011101 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI EVANS, DENIS A · 1993 to 2010
$24.7M
Impact of Neuroinflammation on AD Occurrence: A Bi-Generational Population StudyR01AG073627 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI NEELUM T. AGGARWAL, DENIS A EVANS · 2021 to 2026
$14.0M
Preserving Cognitive Resilience: A Biracial Parent-Offspring Study (18-4674) - Feasibility StudyR01AG058679 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI EVANS, DENIS A, RAJAN, KUMAR B. · 2019 to 2024
$13.8M
Factors Influencing Decline in AD Trends in a Biracial Population StudyRF1AG057532 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RAJAN, KUMAR B. · 2017 to 2017
$1.7M
Nonlinear Models of Cognition Preceding AD in a Biracial Population SampleR01AG051635 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RAJAN, KUMAR B. · 2016 to 2020
$1.5M
Primary prevention, life expectancy, and years lived with and without Alzheimer's dementia in the United StatesR21AG070287 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI DHANA, KLODIAN · 2020 to 2020
$314k
NIA NIH HHS R01 AG011101NIA NIH HHS R01 AG051635NIA NIH HHS R01 AG058679NIA NIH HHS R01 AG073627NIA NIH HHS R21 AG070287NIA NIH HHS RF1 AG057532
6 · The paper itself

Abstract

introductionWe investigated the role of genetic risk and adherence to lifestyle factors on cognitive decline in African Americans and European Americans.

methodsUsing data from the Chicago Health and Aging Project (1993-2012; n = 3874), we defined the genetic risk based on presence of apolipoprotein E (APOE)

resultsAPOE DISCUSSION: A healthy lifestyle was associated with a slower cognitive decline in African and European Americans.

Indexed as

Black or African AmericanCognitive DysfunctionApolipoprotein E4Apolipoproteins EHealthy LifestyleHumansRisk FactorsApolipoprotein E4Apolipoproteins EAfrican Americansapolipoprotein Ecognitive declineEuropean Americansgenetic epidemiologylifestyle factorsrace/ethnicity

Identifiers

PMID34310036
PMCPMC8789942
OpenAlexW3185976411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.