ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The role of APOE ε4 in modulating the relationship between non-genetic risk factors and dementia: a system review and meta-analysis.Journal of neurology · 2025Pooled it
- Global trends and hotspots in exercise therapy for insomnia research: bibliometric and visual analysis.Frontiers in neurology · 2025Pooled it
- Effectiveness of applying auricular acupressure to treat insomnia: a systematic review and meta-analysis.Frontiers in sleep · 2024Pooled it
- Sleep complaints and genetic risk of Alzheimer's disease in older women: associations with memory and tau deposition.The journal of prevention of Alzheimer's disease · 2026Article
- Article
- Non-linear associations between sleep duration and plasma p-tau181 in the Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Waking up to the truth: Associations between sleep disorders and multidomain functional outcomes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Interpretable machine learning models for identifying cognitive impairment in middle-aged and older adults with mild and severe insomnia: development, temporal validation, and clinical external validation.Frontiers in aging neuroscience · 2026Article
- Persistent sleep symptoms in post-COVID syndrome: a Brazilian prospective clinical study.Arquivos de neuro-psiquiatria · 2025Observational
- Sleep chart of biological aging clocks across organs and omics.medRxiv : the preprint server for health sciences · 2025Article
- Sleep quality, APOE ε4, and Alzheimer's disease: associations from two prospective cohort studies and mechanisms by plasma proteomic analysis.BMC medicine · 2025Article
- The causal association between insomnia and cognitive decline: A 2-sample, 2-step multivariable Mendelian randomization study.Medicine · 2025Article
- Long sleep duration, cognitive performance, and the moderating role of depression: A cross-sectional analysis in the Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Moderating effect of APOE ε4 on the association of sleep disturbance and amyloid-β pathology among cognitively normal older adults.Frontiers in aging neuroscience · 2025Article
- An fNIRS-based investigation of cerebral hemodynamic responses during verbal fluency task and n-back task in individuals with mild cognitive impairment.Frontiers in neurology · 2025Article
- Urban-rural differences in the prevalence and influencing factors of insomnia: a cross-sectional study in Foshan, China.Frontiers in psychiatry · 2025Article
- Insomnia Symptoms and Biomarkers of Alzheimer's Disease in the Community.Journal of Alzheimer's disease : JAD · 2023Article
- Disturbed sleep is associated with reduced verbal episodic memory and entorhinal cortex volume in younger middle-aged women with risk-reducing early ovarian removal.Frontiers in endocrinology · 2023Article
- Article
- Possible Neuropathology of Sleep Disturbance Linking to Alzheimer's Disease: Astrocytic and Microglial Roles.Frontiers in cellular neuroscience · 2022Review
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Authors and funding
12 authors.
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Abstract
introductionWe evaluated whether insomnia symptom severity was associated with cognitive function, and whether this relationship was modified by biomarkers associated with Alzheimer's disease risk.
methodsWe examined insomnia symptoms and neuropsychological performance 3.4 years later in 511 dementia-free Framingham Heart Study participants (62.65 ± 8.7 years, 50.9% male). Additionally, we explored insomnia symptoms combined with self-reported short habitual sleep duration and effect modification by apolipoprotein E (APOE) ε4 allele status.
resultsMore severe insomnia symptoms were associated with lower performance on global cognition, and immediate and delayed Logical Memory recall, especially when insomnia symptoms were combined with short sleep duration. The association between insomnia symptoms and poorer memory recall was more pronounced in APOE ε4 allele carriers. DISCUSSION: Insomnia symptom severity was associated with worse subsequent global cognitive and memory performance, which was especially apparent in APOE ε4 allele carriers, suggesting that poor sleep might be particularly detrimental when the brain is already vulnerable to neurodegeneration.
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