ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2021
Association of cardiovascular risk burden with risk of dementia and brain pathologies: A population-based cohort study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 67 citations in OpenAlex.
- Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity.Journal of the American Heart Association · 2023Trial
- Traumatic Brain Injury and the Road to Alzheimer's Disease.Biomedicines · 2026Review
- Association of high-sensitivity cardiac troponin I levels below the sex-specific 99th percentile with late-life dementia: the Perth Longitudinal Study of Ageing Women.Heart (British Cardiac Society) · 2026Article
- Towards a Multidimensional Model of Neurocognitive Disorders (MOND Model): Integrating Evidence from a Critical Review into a Model for Future Research.Journal of personalized medicine · 2026Review
- Long-Term Association of Cardiovascular Risk Burden With Dementia Risk: The Role of Life-Course Confounders in an Analysis of Cumulative and Specific Factors.Journal of the American Heart Association · 2026Article
- Enhancing diagnosis of mild cognitive impairment through brain-heart-gut metabolic networks in whole-body PET imaging.Cell reports. Medicine · 2026Article
- High-sensitivity cardiac troponin I and risk of dementia: the 25-year longitudinal Whitehall II study.European heart journal · 2026Article
- Glycosphingolipids in Dementia: Insights from Mass Spectrometry and Systems Biology Approaches.Biomedicines · 2025Review
- Single nucleus RNA sequencing unveils relationship between microglia and endothelial cells in mixed Alzheimer's disease and vascular pathology.Neurobiology of disease · 2025Article
- MRI markers of cerebrospinal fluid dynamics predict dementia and mediate the impact of cardiovascular risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Micro infarcts are associated with cognitive impairment in neurofibrillary tangle predominant decedents: evidence from the NACC autopsy cohort.Alzheimer's research & therapy · 2025Article
- Sex Differences in the Impact of Atherosclerotic Cardiovascular Risk Burden on Cognitive Health.Journal of the American Heart Association · 2025Article
- Reduced Complexity of Pulse Rate Is Associated With Faster Cognitive Decline in Older Adults.Journal of the American Heart Association · 2025Article
- MRS demonstrates elevated brain glutathione in vascular mild cognitive impairment compared to cognitively normal coronary artery disease controls.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Cardiovascular health and its association with dementia, Parkinson's Disease, and mortality among UK older adults.Brain, behavior, & immunity - health · 2025Article
- A point-based cognitive impairment scoring system for southeast Asian adults.The journal of prevention of Alzheimer's disease · 2025Article
- M-ECG: extracting heart signals with a novel computational analysis of magnetoencephalography data.Frontiers in neuroimaging · 2025Article
- Neurofilament Light Chain as a Biomarker of Global Cognition in Individuals With Possible Vascular Mild Cognitive Impairment.Journal of geriatric psychiatry and neurology · 2025Article
- Association of amyloid and cardiovascular risk with cognition: Findings from KBASE.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Knowledge, perceptions, and feelings associated with Alzheimer's disease and related dementias: a qualitative study among middle-aged latinas residing in an underserved agricultural community in California.BMC public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
introductionThe impact of cardiovascular risk burden on brain pathologies remains unclear. We aimed to examine the association of the Framingham General Cardiovascular Risk Score (FGCRS) with dementia risk, and brain pathologies.
methodsWithin the Rush Memory and Aging Project, 1588 dementia-free participants were assessed on FGCRS at baseline and followed up to 21 years. During the follow-up, 621 participants died and underwent autopsies.
resultsThe multi-adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) of FGCRS were 1.03 (1.00-1.07) for dementia and 1.04 (1.01-1.07) for Alzheimer's disease (AD) dementia. Further, a higher FGCRS was associated with higher gross chronic cerebral infarctions (odds ratio [OR] 1.08, 95% CI 1.02-1.14), cerebral atherosclerosis (OR 1.10, 95% CI 1.03-1.17), and global AD pathology (OR 1.06, 95% CI 1.01-1.12).
conclusionsA higher FGCRS is associated with an increased risk of dementia and AD dementia. Both vascular and AD pathologies in the brain may underlie this association.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.