ArticleEuropean journal of pain (London, England)2022
Conditioned pain modulation and pain sensitivity in functional somatic disorders: The DanFunD study.
Article in European journal of pain (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Gut microbiota composition outperforms chronological age in predicting systemic inflammation and incident disease risk.Nature communications · 2026Article
- Are Conditioned Pain Modulation and Pain Sensitivity Risk Factors for the Development of Functional Somatic Disorder? A Longitudinal Population-Based Study.European journal of pain (London, England) · 2026Article
- "Do Doctors and Patients Have Different Understandings of Pain?" - A Pilot Study of Different Perspectives and Understandings of Pain in Clinical Pain Research.Journal of pain research · 2025Article
- Conditioned pain modulation and pain sensitivity in functional somatic disorders: The DanFunD study.European journal of pain (London, England) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisrupted pain regulation has been proposed as a component in functional somatic disorders (FSD). The objective of this study was to examine a general population sample, encompassing three delimitations of FSD while assessing pain sensitivity and conditioning pain modulation (CPM).
methodsPressure pain thresholds (PPTs) at the tibialis and trapezius muscles were recorded at baseline. During cold pressor stimulation of the hand, the tibialis PPTs were re-assessed and the difference from baseline measures defined the CPM effect. Participants (n = 2,198, 53% females) were randomly selected from the adult Danish population. FSD was established by self-reported symptom questionnaires.
resultsWith a few exceptions, only weak associations were seen between PPTs and CPM in cases with FSD (p > .1). A high PPT was associated with lower odds of having multi-organ bodily distress syndrome (OR
conclusionHowever, only PPT measured over the trapezius muscle were still significant after correction for multiple testing for the symptom profile characterized by all symptoms. Findings from this study do not support altered pain regulation in questionnaire-based FSD which is in contrast with the existing presumption. Further epidemiological studies in this field are needed. SIGNIFICANCE: Disrupted pain regulation as measured by abnormal pain thresholds has been hypothesized as a central mechanism in Functional Somatic Disorders (FSD). The hypothesis has been raised in clinical setting where patients presented subjective and objective features of hypersensitivity. The present population-based study does not support this notion. This points to the importance of further studies into the underlying pathophysiology mechanisms of FSD.
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