ReviewAnnals of the New York Academy of Sciences2021
Pediatric thiamine deficiency disorders in high-income countries between 2000 and 2020: a clinical reappraisal.
Review in Annals of the New York Academy of Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Thiamine (Vitamin B1)-An Essential Health Regulator.Nutrients · 2025Review
- Thiamine Deficiency Secondary to Pain-Induced Oral Aversion.Clinical pediatrics · 2025Article
- Thiamine deficiency secondary to intestinal surgery leading to shoshin beriberi and Wernicke encephalopathy: a case report.Frontiers in pediatrics · 2025Article
- Wernicke encephalopathy: a mini review of the clinical spectrum, atypical manifestations, and diagnostic challenges.Frontiers in neurology · 2025Review
- Shoshin Beriberi in a Child With Intestinal Failure: A Case Report.Critical care explorations · 2024Article
- Thiamine: An indispensable regulator of paediatric neuro-cardiovascular health and diseases.European journal of pediatrics · 2024Review
- Wernicke encephalopathy in a pediatric patient with cannabinoid hyperemesis: A novel case report.JPGN reports · 2024Article
- Thiamine deficiency in diabetes, obesity and bariatric surgery: Recipes for diabetic ketoacidosis.Journal of family medicine and primary care · 2024Review
- The importance of thiamine (vitamin B1) in humans.Bioscience reports · 2023Article
- Severe Lactic Acidosis Caused by Thiamine Deficiency in a Child with Relapsing Acute Lymphoblastic Leukemia: A Case Report.Children (Basel, Switzerland) · 2023Article
- Association Between Vitamin Deficiencies and Ophthalmological Conditions.Clinical ophthalmology (Auckland, N.Z.) · 2023Review
- Thiamine deficiency in pregnancy and lactation: implications and present perspectives.Frontiers in nutrition · 2023Review
- Editorial: Case reports in pediatric gastroenterology, hepatology and nutrition 2022.Frontiers in pediatrics · 2023Article
- Thiamine deficiency in Gambian women of reproductive age.Annals of the New York Academy of Sciences · 2022Article
- Thiamine as a Possible Neuroprotective Strategy in Neonatal Hypoxic-Ischemic Encephalopathy.Antioxidants (Basel, Switzerland) · 2021Review
- A fresh look at thiamine deficiency-new analyses by the global thiamine alliance.Annals of the New York Academy of Sciences · 2021Review
- Anaesthesia and intensive care management of shoshin beriberi in perioperative period in young adult.Annals of cardiac anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Often thought to be a nutritional issue limited to low- and middle-income countries (LMICs), pediatric thiamine deficiency (PTD) is perceived as being eradicated or anecdotal in high-income countries (HICs). In HICs, classic beriberi cases in breastfed infants by thiamine-deficient mothers living in disadvantaged socioeconomic conditions are thought to be rare. This study aims to assess PTD in HICs in the 21st century. Literature searches were conducted to identify case reports of PTD observed in HICs and published between 2000 and 2020. The analyzed variables were age, country, underlying conditions, clinical manifestations of PTD, and response to thiamine supplementation. One hundred and ten articles were identified, totaling 389 PTD cases that were classified into four age groups: neonates, infants, children, and adolescents. Eleven categories of PTD-predisposing factors were identified, including genetic causes, lifestyle (diabetes, obesity, and excessive consumption of sweetened beverages), eating disorders, cancer, gastrointestinal disorders/surgeries, critical illness, and artificial nutrition. TD-associated hyperlactatemia and Wernicke encephalopathy were the most frequent clinical manifestations. The circumstances surrounding PTD in HICs differ from classic PTD observed in LMICs and this study delineates its mutiple predisposing factors. Further studies are required to estimate its magnitude. Awareness is of utmost importance in clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.