Evidence map›Paper›PMID 34309834›Full record

Trial reportClinical and experimental immunology2021

CD4

Smadar Gertel, Ari Polachek, Victoria Furer, David Levartovsky, Ori Elkayam

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Clinical and experimental immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. CD4Clinical and experimental immunology · 2021
    Trial
  2. Review
  3. Article
  4. LAG-3 palmitoylation-inducing dysfunction of decidual CD4Molecular medicine (Cambridge, Mass.) · 2025
    Article
  5. Article
  6. Review
  7. CD4iScience · 2023
    Article
  8. Fewer LAG-3Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Smadar GertelDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.ORCID 0000-0001-7949-7184
Ari PolachekDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Victoria FurerDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
David LevartovskyDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Ori ElkayamDepartment of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Tel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with T cell dysregulation. The lymphocyte-activation gene (LAG)-3 is one of the regulatory receptors expressed on T cells in a soluble form. LAG-3 expression on T cells was analyzed in vitro in PsA patients with minimal disease activity (MDA), active disease (non-MDA) and healthy controls. In cultured in-vitro peripheral blood mononuclear cells (PBMCs), LAG-3 expression on CD4

Indexed as

Antigens, CDArthritis, PsoriaticCD4-Positive T-LymphocytesFemaleHumansInterleukin-17Lymphocyte Activation Gene 3 ProteinMaleMiddle AgedTumor Necrosis Factor-alphaAntigens, CDInterleukin-17Lag3 protein, humanLymphocyte Activation Gene 3 Proteinsoluble LAG-3 protein, humanTumor Necrosis Factor-alphaarthritis (including rheumatoid arthritis)inhibitory/activating receptorsT cells

Identifiers

PMID34309834
PMCPMC8506121
OpenAlexW3186889502

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.